Comparison of delayed gadolinium enhanced MRI of cartilage (dGEMRIC) using inversion recovery and fast T1 mapping sequences
Comparison of delayed gadolinium enhanced MRI of cartilage (dGEMRIC) using inversion recovery and fast T1 mapping sequences
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DOI：
10.1002/mrm.21726
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发表时间：
2008-10-01
影响因子：
3.3
通讯作者：
Kim, Young-Jo
中科院分区：
文献类型：
--
作者：
Mamisch, Tallal Charles;Dudda, Marcel;Kim, Young-Jo
在早期骨关节炎的初步临床研究中，延迟钆增强MRI（dGEMRIC）技术已显示出有希望的结果。目前，其更广泛的接受受到扫描时间长和需要后处理来计算T1图的限制。提出了一种基于两幅扰相梯度回波图像的快速T1标测成像技术。在体模研究中，一个适当的翻转角组合优化的中心T1的756至955毫秒产生了良好的协议与T1测量使用反转恢复技术在200至900毫秒的范围内，在正常和患病软骨的利益。通过使用反转恢复和快速2角度T1标测技术（中心T1 756 ms）对26个髋关节进行连续成像进行体内验证。观察到Pearson相关系数R2为0.74的良好相关性，Bland-Altman图显示无系统偏倚。
The delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) technique has shown promising results in pilot clinical studies of early osteoarthritis. Currently, its broader acceptance is limited by the long scan time and the need for postprocessing to calculate the T1 maps. A fast T1 mapping imaging technique based on two spoiled gradient echo images was implemented. In phantom studies, an appropriate flip angle combination optimized for center T1 of 756 to 955 ms yielded excellent agreement with T1 measured using the inversion recovery technique in the range of 200 to 900 ms, of interest in normal and diseased cartilage. In vivo validation was performed by serially imaging 26 hips using the inversion recovery and the Fast 2 angle T1 mapping techniques (center T1 756 ms). Excellent correlation with Pearson correlation coefficient R2 of 0.74 was seen and Bland-Altman plots demonstrated no systematic bias.