Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site.
Variance and covariances of the numbers of synonymous and nonsynonymous substitutions per site.
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每个位点的同义和非同义替换数量的方差和协方差。
DOI：
10.1093/oxfordjournals.molbev.a040140
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发表时间：
1994
影响因子：
10.7
通讯作者：
Nei,M
中科院分区：
文献类型：
--
作者：
Ota,T;Nei,M
Nei和Gojobori（1986）开发了一种简单的方法来估计每个位点的同义（ds）和非同义（dN）取代的数量。在本文中，我们已经开发出一种方法来计算方差和协方差的ds的和dN的和比例的同义（PS）和非同义（PN）的差异。我们还开发了一种方法来计算方差的平均dS，dN，pS，pN，没有构建一个系统发育树的基因。我们已经进行了计算机模拟的基础上简单的进化模型，并已表明，新方法提供了良好的估计方差和协方差。
Nei and Gojobori (1986) developed a simple method to estimate the numbers of synonymous (ds) and nonsynonymous (dN) substitutions per site. In the present paper, we have developed a method for computing variances and covariances of ds's and dN's and of the proportions of synonymous (ps) and nonsynonymous (pN) differences. We also have developed a method for computing the variances of mean dS, dN, pS, pN, without constructing a phylogenetic tree of the genes. We have conducted computer simulations based on simple evolutionary models and have shown that the new method gives good estimates of variances and covariances.