Retinoids: Dissolving the Calcification Paradox.
Retinoids: Dissolving the Calcification Paradox.
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类维生素A：解决钙化悖论。
DOI：
10.1161/atvbaha.119.313854
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
StHilaire,Cynthia
中科院分区：
文献类型：
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作者：
StHilaire,Cynthia
人体中的钙化理想地保留在骨骼和牙齿中;然而，病理性钙化可以作为对炎症，损伤和创伤等损伤的适应性反应而出现。1异位钙化可在全身几乎所有软组织中形成2 -6;然而，主要表现为心血管组织。在皮肤的微血管中可以发现钙化，如在钙化耐受中，7在动脉粥样硬化斑块的坏死核心中，8在沿着沿着受损弹性膜的血管的富含平滑肌细胞的中间层中，9，10以及在心脏瓣膜的小叶中。11冠状动脉钙化评分现在是评估有症状和无症状患者主要不良心血管事件风险的最常用指标。12
Calcification in the human body is ideally reserved for bones and teeth; however, pathological calcification can arise as an adaptive response to insults such as inflammation, injury, and trauma. 1 Ectopic calcification can form in nearly all soft tissues throughout the body2–6; however, the primary manifestation occurs in cardiovascular tissues. Calcification can be found in the microvessels of the skin, as in calciphylaxis, 7 in the necrotic core of atherosclerotic plaques, 8 in the smooth muscle cell-rich medial layer of vessels along damaged elastic lamina, 9, 10 as well as in the leaflets of the heart valves. 11 Coronary artery calcium score is now the metric most commonly used to assess the risk for major adverse cardiovascular events in both symptomatic and nonsymptomatic patients. 12