Isolation of a new compound, 2-butanone 4-glucopyranoside 6′-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb
Isolation of a new compound, 2-butanone 4-glucopyranoside 6′-O-gallate and other 8 compounds from the anti-inflammatory leave extracts of Memecylon edule Roxb
复制标题
从Memecylon edule Roxb抗炎叶提取物中分离得到新化合物2-丁酮4-吡喃葡萄糖苷6′-O-没食子酸酯等8个化合物
作者：
S. Nualkaew;S. Thongpraditchote;Y. Wongkrajang;K. Umehara;H. Noguchi
摘要本研究旨在分离和鉴定膜木属植物中的化合物。通过色谱法纯化化合物，并根据光谱分析（UV、MS和NMR）确定其结构。测试了主要分离化合物的抗炎活性。M.从杜仲叶中分离得到一个新化合物2-丁酮-4-吡喃葡萄糖苷-6 ′-O-没食子酸酯（1），它与8个已知化合物，即3，3 ′-二-O-甲基鞣花酸-4-O-β-D-吡喃葡萄糖苷（2），表没食子儿茶素-3-O-没食子酸酯（3），（2 R，3R）-二氢杨梅素-4 ′-β-D-吡喃葡萄糖苷（4），杨梅素-3-O-α-L-吡喃鼠李糖苷（5），苄基-（6-O-α-L-阿拉伯呋喃糖基）O-β-d-吡喃葡萄糖苷（6）、苄基-（6-O-α-L-吡喃鼠李糖基）O-β-d-吡喃葡萄糖苷（7）、2-苯乙基-（6-O-β-d-芹菜呋喃糖基）-O-β-d-吡喃葡萄糖苷（8）和苯甲酸甲酯2-（6-O-α-L-鼠李糖基）-O-β-d-吡喃葡萄糖苷（9）。所有化合物均为首次从该植物中分离得到。主要化合物（2、3和5）显示出显著的抗炎活性。最后，M.人们认识到，依那普利是酚类化合物的良好来源，这些化合物可能有助于提取物的抗炎活性。
Abstract This present study was designed to isolate the compounds of Memecylon edule. The chemical compounds were purified by chromatographic methods and their structures were established on the basis of spectroscopic analyses (UV, MS and NMR). The major isolated compounds were tested for anti-inflammatory activity. The methanolic extracts of M. edule leaves gave a new compound 2-butanone 4-glucopyranoside 6′-O-gallate (1) with eight known compounds, namely, 3,3′-di-O-methylellagic acid 4-O-β-d-glucopyranoside (2), epigallocatechin-3-O-gallate (EGCG) (3), (2R, 3R)–dihydromyricetin-4′-β-d-glucopyranoside (4), myricetin-3-O-α-l-rhamnopyranoside (5), benzyl-(6-O-α-L arabinofuranosyl) O-β-d-glucopyranoside (6), benzyl-(6-O-α-l-rhanmopyranosyl) O-β-d-glucopyranoside (7), 2-phenylethyl-(6-O-β-d-apiofuranosyl)-O-β-d-glucopyranoside (8) and methyl benzoate 2-(6-O-α-l-rhamnosyl)-O-β-d-glucopyranoside (9). All compounds were isolated for the first time from this plant. The major compounds (2, 3 and 5) exhibited significant anti-inflammatory activity. In conclusion, M. edule was recognised to be a good source for phenolic compounds and these compounds may contribute to anti-inflammatory activity of the extract.
影响因子：
4.2
作者：
Yang, FJ;de Villers, WJS;Varilek, GW
通讯作者：
Varilek, GW
影响因子：
7.4
作者：
Ahmed, S;Rahman, A;Haqqi, TM
通讯作者：
Haqqi, TM