Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
Loneliness and stress-related inflammatory and neuroendocrine responses in older men and women
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DOI：
10.1016/j.psyneuen.2012.03.016
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发表时间：
2012-11-01
影响因子：
3.7
通讯作者：
Steptoe, Andrew
中科院分区：
文献类型：
--
作者：
Hackett, Ruth A.;Hamer, Mark;Steptoe, Andrew
孤独是死亡率和心血管疾病发病率增加的预测因素。炎症是孤独可能影响健康的潜在途径。该研究的目的是调查孤独感与炎症白细胞介素 6 (IL-6)、白细胞介素 1 受体拮抗剂 (IL-1Ra) 和单核细胞趋化蛋白 1 (MCP-1) 对标准化精神压力的反应之间的关系。第二个目的是评估皮质醇反应的个体差异是否影响孤独和炎症之间的假设关系。唾液样本和血液样本是从 Whitehall II 队列中的 524 名健康中年男性和女性身上采集的，这些样本是在基线、压力任务结束后立即以及 45 分钟后采集的。使用修订后的加州大学洛杉矶分校孤独量表来测量孤独感。女性的孤独感越强，对心理压力的 IL-6 (p = 0.044) 和 IL-1Ra (p = 0.006) 反应越大，MCP-1 (p < 0.001) 水平越高，与年龄、职业等级、体重指数和吸烟状况无关。在男性中没有观察到关联。皮质醇反应性与女性的孤独感呈负相关，成为皮质醇反应者的几率随着孤独感的增加而降低，与协变量无关（p = 0.008）。孤独对女性健康的影响可能部分是通过炎症和神经内分泌系统的失调来调节的。 (c) 2012 Elsevier Ltd. 保留所有权利。
Loneliness is a predictor of mortality and increased cardiovascular morbidity. Inflammation is a potential pathway through which loneliness might impact health. The aim of the study was to investigate the relationship between loneliness and inflammatory interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1Ra) and monocyte chemotactic protein-1 (MCP-1) responses to standardized mental stress. A secondary purpose was to evaluate whether individual variations in cortisol responses influenced the hypothesised relationship between loneliness and inflammation. Saliva samples and blood were taken from 524 healthy middle-aged men and women from the Whitehall II cohort at baseline, immediately after the stress tasks and 45 min later. Loneliness was measured using the revised UCLA loneliness scale. Greater loneliness was associated with larger IL-6 (p = 0.044) and IL-1Ra (p = 0.006) responses to psychological stress and higher MCP-1 (p < 0.001) levels in women, independently of age, grade of employment, body mass index and smoking status. No associations were observed in men. Cortisol responsivity was inversely related to loneliness in women, with the odds of being a cortisol responder decreasing with increased loneliness independently of covariates (p = 0.008). The impact of loneliness on health in women may be mediated in part through dysregulation of inflammatory and neuroendocrine systems. (c) 2012 Elsevier Ltd. All rights reserved.