Molecular diversity of voltage-gated sodium channel α and β subunit mRNAs in human tissues
Molecular diversity of voltage-gated sodium channel α and β subunit mRNAs in human tissues
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DOI：
10.1016/j.ejphar.2006.04.025
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发表时间：
2006-07-10
影响因子：
5
通讯作者：
Pinto, Francisco M.
中科院分区：
文献类型：
--
作者：
Candenas, Luz;Seda, Marian;Pinto, Francisco M.
Voltage-gated Na+ channels are composed of one a subunit and one or more auxiliary subunits. A reverse transcription-polymerase chain reaction assay was used to analyse the expression of the nine known a subunits (Na(v)1.1-Nav1.9) in 20 different human tissues. The mRNA expression of the currently known subunits ( 1, 2, 03 and 04) was also assessed. The mRNAs of voltage-gated Na+ channel CL and 0 subunits were found in a wide variety of human tissues assayed and were present in neuronal and non-neuronal types of cells. These data suggest that, in addition to its well-established role in skeletal muscle, cardiac cells and neurons, voltage-gated Na+ channels might play important, still undetermined local roles in the regulation of cellular functions. These channels could emerge in the next future as potential, new therapeutic targets in the treatment of visceral diseases. (c) 2006 Elsevier B.V All rights reserved.
