Concerted Catalysis by Nanocellulose and Proline in Organocatalytic Michael Additions
Concerted Catalysis by Nanocellulose and Proline in Organocatalytic Michael Additions
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DOI：
10.3390/molecules24071231
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发表时间：
2019-03-29
期刊：
影响因子：
4.6
通讯作者：
Kitaoka, Takuya
中科院分区：
文献类型：
--
作者：
Ranaivoarimanana, Naliharifetra Jessica;Kanomata, Kyohei;Kitaoka, Takuya
纤维素纳米纤维（CNFs）作为催化剂在各种反应中的应用引起了人们的广泛关注。有机催化剂已经成为绿色有机合成中金属基催化剂的可持续替代品，其中含有CNF的协同体系有望提供下一代催化。在此，我们首次报道了包含2，2，6，6-四甲基哌啶1-氧基（克里思）-氧化的CNF和脯氨酸的意想不到的组合的代表性有机催化剂在不对称迈克尔加成中显示出显著增强的催化活性。
Cellulose nanofibers (CNFs) have recently attracted much attention as catalysts in various reactions. Organocatalysts have emerged as sustainable alternatives to metal-based catalysts in green organic synthesis, with concerted systems containing CNFs that are expected to provide next-generation catalysis. Herein, for the first time, we report that a representative organocatalyst comprising an unexpected combination of 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-oxidized CNFs and proline shows significantly enhanced catalytic activity in an asymmetric Michael addition.