Rhythm-specific modulation of the sensorimotor network in drug-naive patients with Parkinson's disease by levodopa
Rhythm-specific modulation of the sensorimotor network in drug-naive patients with Parkinson's disease by levodopa
复制标题
DOI：
10.1093/brain/awt007
复制
发表时间：
2013-03-01
期刊：
影响因子：
14.5
通讯作者：
Tedeschi, Gioacchino
中科院分区：
文献类型：
--
作者：
Esposito, Fabrizio;Tessitore, Alessandro;Tedeschi, Gioacchino
脑活动在休息期间的特征是缓慢（0.01-0.1赫兹）波动的血氧水平依赖功能磁共振成像信号。这些波动被组织成称为静息状态网络的功能性连接网络，在解剖学上对应于特定的神经元回路。鉴于帕金森病以感觉运动通路功能障碍为主要特征，可受左旋多巴的影响，本研究对未用药的帕金森病患者急性左旋多巴后感觉运动静息状态网络功能连通性的变化进行了研究。采用双盲安慰剂对照设计，对20例未使用药物的帕金森病患者在口服左旋多巴或安慰剂之前和后60分钟进行静息状态功能磁共振成像。记录了18名年龄和性别匹配的健康志愿者的对照静息状态功能磁共振成像数据。采用独立分量分析提取静息状态网络图和相关时程谱特征。在解剖学水平上，左旋多巴增强了辅助运动区的感觉运动网络功能连通性，与未接受药物治疗的帕金森病患者相比，该区域的信号波动减少。在频谱频率水平上，左旋多巴在感觉运动网络的一个选择性频带中刺激了这些波动。已报道的左旋多巴对感觉运动网络拓扑和频谱特征的影响证实，感觉运动系统是急性左旋多巴给药帕金森病患者的靶点。此外，辅助运动区的区域变化反映了运动功能的改善，多巴胺前体诱导的节律特异性调节揭示了帕金森病药物刺激的一个新方面，进一步加深了对左旋多巴作用的理解。
Brain activity during rest is characterized by slow (0.01-0.1 Hz) fluctuations of blood oxygenation level-dependent functional magnetic resonance imaging signals. These fluctuations are organized as functional connectivity networks called resting-state networks, anatomically corresponding to specific neuronal circuits. As Parkinson's disease is mainly characterized by a dysfunction of the sensorimotor pathways, which can be influenced by levodopa administration, the present study investigated the functional connectivity changes within the sensorimotor resting-state network in drug-naive patients with Parkinson's disease after acute levodopa administration. Using a double-blind placebo-controlled design, resting-state functional magnetic resonance imaging was carried out in 20 drug-naive patients with Parkinson's disease, immediately before and 60 min after, oral administration of either levodopa or placebo. Control resting-state functional magnetic resonance imaging data were recorded in 18 age- and sex-matched healthy volunteers. Independent component analysis was performed to extract resting-state network maps and associated time-course spectral features. At the anatomical level, levodopa enhanced the sensorimotor network functional connectivity in the supplementary motor area, a region where drug-naive patients with Parkinson's disease exhibited reduced signal fluctuations compared with untreated patients. At the spectral frequency level, levodopa stimulated these fluctuations in a selective frequency band of the sensorimotor network. The reported effects induced by levodopa on sensorimotor network topological and spectral features confirm that the sensorimotor system is a target of acute levodopa administration in drug-naive patients with Parkinson's disease. Moreover, while the regional changes in supplementary motor area reflect the functional improvement in motor function, the rhythm-specific modulation induced by the dopamine precursor discloses a novel aspect of pharmacological stimulation in Parkinson's disease, adding further insight to the comprehension of levodopa action.