Distribution of cardiac output during static exercise in the conscious cat.
Distribution of cardiac output during static exercise in the conscious cat.
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清醒的猫静态运动时心输出量的分布。
DOI：
10.1152/jappl.1982.52.3.642
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Mitchell,JH
中科院分区：
文献类型：
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作者：
Diepstra,G;Gonyea,W;Mitchell,JH
在有意识的猫中测量流向主要器官的血流量，以研究自愿静态（等长）运动期间心输出量分布的变化。对五只动物进行操作性训练，使其在固定阻力下握住杠子 30 秒。通过将 25 微米放射性微球注射到左心房或左心室，在休息和运动期间测量器官流量。运动期间观察到心率（18%）、平均动脉压（25%）、左心室收缩压（17%）和左心室发育率（26%）增加。静态运动使流向肾脏 (-1.09 +/- 0.24)、脾脏 (-0.85 +/- 0.21) 和运动肌肉 (+0.13 +/- 0.08) 的流量 (ml . min-1 .g-1) 产生显着变化，而流向肝脏、心脏、大脑和非运动肌肉的流量与对照水平相比没有显着变化。左肾去神经支配消除了运动期间流向该肾脏的流量减少。因此，静态运动似乎会显着增加流向运动肌肉的血流量，并显着减少流向脾脏和肾脏的血流量。肾血流量的减少是由神经机制介导的。
Blood flows to major organs were measured in conscious cats to study the changes in the distribution of cardiac output during voluntary static (isometric) exercise. Five animals were operantly conditioned to hold a bar against a fixed resistance for 30 s. Organ flows were measured during rest and exercise by injecting 25-micrometer radioactive microspheres into the left atrium or left ventricle. Increases were observed during exercise in heart rate (18%), mean arterial pressure (25%), left ventricular systolic pressure (17%), and rate of left ventricular development (26%). Static exercise produced significant changes in flow (ml . min-1 .g-1) to the kidneys (-1.09 +/- 0.24), spleen (-0.85 +/- 0.21), and exercising muscles (+0.13 +/- 0.08), while flows to liver, heart, brain, and nonexercising muscle were not significantly changed from control levels. Denervation of the left kidney abolished the decrease in flow to that kidney during exercise. Thus, static exercise appears to produce a significant increase in blood flow to exercising muscles and significant reductions in blood flow to spleen and kidneys. The reduction in renal blood flow is mediated by a neural mechanism.