Restoration of peripheral blood natural killer and B cell levels in patients affected by rheumatoid and psoriatic arthritis during etanercept treatment
Restoration of peripheral blood natural killer and B cell levels in patients affected by rheumatoid and psoriatic arthritis during etanercept treatment
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DOI：
10.1111/cei.12335
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发表时间：
2014-07-01
影响因子：
4.6
通讯作者：
Perricone, R.
中科院分区：
文献类型：
--
作者：
Conigliaro, P.;Triggianese, P.;Perricone, R.
依那西普 (ETN) 是一种抗肿瘤坏死因子 (TNF) 药物，用于治疗类风湿关节炎 (RA) 和银屑病关节炎 (PsA)。很少有研究关注抗 TNF-α对外周血细胞的影响。我们的目的是评估 RA 和 PsA 患者在 ETN 治疗期间的外周血细胞，并探讨它们与疾病活动的关系。开始 ETN 的 RA (n=82) 和 PsA (n=32) 患者被纳入研究，并在 ETN 治疗开始前以及 14、22、54 和 102 周后进行前瞻性评估。根据 28 个关节的疾病活动评分 (DAS28)、临床反应和实验室检查结果对患者进行了研究。通过免疫表型分析来表征自然杀伤 (NK) 细胞、B 细胞和 T 细胞。与对照组相比，ETN 治疗前 RA 和 PsA 患者的 NK 和 B 细胞计数均减少。基线时 RA 患者的 DAS28 与 B 细胞计数之间存在负相关性。在 ETN 治疗期间，RA 和 PsA 患者观察到 NK 和 B 细胞持续显着增加至正常水平。 RA 和 PsA 患者中 NK 细胞计数的增加与 ETN 的良好至中等临床反应相关。在 ETN 治疗期间，RA 和 PsA 患者的外周血 NK 和 B 细胞水平得到恢复。观察到 NK 和 B 细胞与疾病活动之间的相关性，表明这些效应可能是由 ETN 治疗介导的。
Etanercept (ETN) is an anti-tumour necrosis factor (TNF)- agent used in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Few studies focused on the effects of anti-TNF- on peripheral blood cells. We aimed to evaluate peripheral blood cells in RA and PsA patients during ETN treatment and to explore their relationships with disease activity. RA (n=82) and PsA (n=32) patients who started ETN were included into the study and evaluated prospectively before the beginning of ETN therapy and after 14, 22, 54 and 102 weeks. Patients were studied in terms of disease activity score on 28 joints (DAS28), clinical response and laboratory findings. Natural killer (NK) cells, B cells and T cells were characterized by immunophenotyping. Both the RA and the PsA patients showed reduced NK and B cell count before ETN treatment compared with controls. A negative correlation was demonstrated between DAS28 and B cell count in RA patients at baseline. Sustained significant increase of NK and B cells up to normal levels was observed in RA and PsA patients along ETN treatment. Increase of NK cell count was associated with a good-moderate clinical response to ETN in both RA and PsA patients. During ETN treatment peripheral blood NK and B cells levels were restored in RA and PsA patients. Correlations between NK and B cells with disease activity were observed, suggesting that those effects could be mediated by ETN treatment.