Asymmetric Allylic C-H Alkylation of Allyl Ethers with 2-Acylimidazoles
Asymmetric Allylic C-H Alkylation of Allyl Ethers with 2-Acylimidazoles
复制标题
烯丙基醚与 2-酰基咪唑的不对称烯丙基 C-H 烷基化
DOI：
10.1021/jacs.9b05247
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发表时间：
2019
影响因子：
15
通讯作者：
Gong Liu Zhu
中科院分区：
文献类型：
--
作者：
Wang Tian Ci;Fan Lian Feng;Shen Yang;Wang Pu Sheng;Gong Liu Zhu
通过手性磷酰胺-钯催化，建立了烯丙基醚的不对称烯丙基C-H烷基化反应，得到了多种手性2-酰基咪唑，收率中高，对映选择性高。此外，该方案可应用于快速激肽受体拮抗剂的简洁不对称合成。
An asymmetric allylic C–H alkylation of allyl ethers has been established by chiral phosphoramidite-palladium catalysis, affording a wide variety of functionalized chiral 2-acylimidazoles in moderate to high yields and with high levels of enantioselectivity. Moreover, this protocol could be applied to a concise asymmetric synthesis of a tachykinin receptor antagonist.