Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli
Selectivity of neural stimulation in the auditory system: a comparison of optic and electric stimuli
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DOI：
10.1117/1.2714296
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发表时间：
2007-03-01
影响因子：
3.5
通讯作者：
Richter, Claus-Peter
中科院分区：
文献类型：
--
作者：
Izzo, Agnella D.;Suh, Eul;Richter, Claus-Peter
脉冲，中红外激光最近被研究作为一种方法来刺激神经活动。光学刺激神经优于电刺激，特别是应用更多空间受限的神经刺激。我们报告的实验中，沙鼠听觉系统的刺激，光辐射，声音的音调，或电流的结果。免疫组织化学染色的蛋白质c-FOS显示的兴奋的蔓延。我们证明了一个空间选择性激活的神经元使用激光，只有神经元在直接的光路刺激。这种c-FOS标记模式与电刺激后的模式相反。电刺激导致标记的、激活的神经元的大的、空间上更扩展的群体。在听觉系统中，神经的光学刺激会对人工耳蜗的性能、电流传播产生重大影响。(C)2007年，由光学仪器工程师协会（Society of Photo-Optical Instrumentation Engineers）主办。
Pulsed, mid-infrared lasers were recently investigated as a method to stimulate neural activity. There are significant benefits of optically stimulating nerves over electrically stimulating, in particular the application of more spatially confined neural stimulation. We report results from experiments in which the gerbil auditory system was stimulated by optical radiation, acoustic tones, or electric current. Immunohistochemical staining for the protein c-FOS revealed the spread of excitation. We demonstrate a spatially selective activation of neurons using a laser; only neurons in the direct optical path are stimulated. This pattern of c-FOS labeling is in contrast to that after electrical stimulation. Electrical stimulation leads to a large, more spatially extended population of labeled, activated neurons. In the auditory system, optical stimulation of nerves could have a significant impact on the performance of cochlear implants, electric current spread. (C) 2007 Society of Photo-Optical Instrumentation Engineers.