The cooperative action of angiotensin II with subluteolytic administration of PGF2alpha in inducing luteolysis and oestrus in the cow.
The cooperative action of angiotensin II with subluteolytic administration of PGF2alpha in inducing luteolysis and oestrus in the cow.
复制标题
血管紧张素 II 与 PGF2α 的亚黄体分解给药在诱导牛黄体分解和发情中的协同作用。
作者：
K. Hayashi;J. Tanaka;K. Hayashi;M. Hayashi;M. Ohtani;A. Miyamoto
有证据表明，有效的血管收缩素II （Ang II）调节黄体功能。在本研究中，研究了单独或联合预处理半溶血imm剂量的PGF（2alpha）对血浆黄体酮浓度、黄体消退和发情周期持续时间的影响。奶牛随机接受以下两种输注：(i)在给药30分钟后静脉注射500微升生理盐水（对照组，n = 7）；（ii）在静脉注射半溶性剂量（125微克）PGF（2alpha）类似物（1/4 PGF(2alpha), n = 5） 30分钟后500微公升生理盐水；（iii）在给药30分钟后，在500微升生理盐水中加入2 mg Ang II (Ang II, n = 5)；或（iv）在发情周期第12天ig半溶性剂量（125微克）PGF（2alpha）类似物（1/4 PGF(2alpha)/Ang II, n = 6） 30分钟后，在500微利生理盐水中加入2mg Ang II。对照组、1/4 PGF（2 α）或Ang II治疗组血浆孕酮浓度无显著变化。1/4 PGF(2alpha)/Angⅱ组降低血浆孕酮浓度，诱导黄体溶解和发情。全剂量（500 μ g） PGF（2alpha）组（处理后3.1 +/- 0.2（平均+/- SEM） d）的发情期明显早于1/4 PGF(2alpha)/Angⅱ组（处理后4.8 +/- 0.2 d） （P < 0.05）。本研究的结果表明，在静脉注射半溶血剂量的PGF（2alpha）类似物后，静脉注射Ang II可诱导黄体溶解和发情。因此，这些结果支持了Ang II与奶牛黄体退化过程直接相关的论点。
There is evidence that the potent vasoconstrictor angiotensin II (Ang II) regulates luteal functions. In the present study, the effect of an intraluteal injection of Ang II alone or in combination with pretreatment with a subluteolytic i.m. dose of PGF(2alpha) on the concentration of plasma progesterone, corpus luteum regression and duration of the oestrous cycle was investigated. Cows were assigned randomly to receive an intraluteal injection of either: (i) 500 microl saline 30 min after i.m. administration of saline (control, n = 7); (ii) 500 microl saline 30 min after i.m. administration of a subluteolytic dose (125 microg) of a PGF(2alpha) analogue (1/4 PGF(2alpha), n = 5); (iii) 2 mg Ang II in 500 microl saline 30 min after i.m. administration of saline (Ang II, n = 5); or (iv) 2 mg Ang II in 500 microl saline 30 min after i.m. administration of a subluteolytic dose (125 microg) of the PGF(2alpha) analogue (1/4 PGF(2alpha)/Ang II, n = 6) on day 12 of the oestrous cycle. There were no significant changes in plasma progesterone concentrations in the control, 1/4 PGF(2alpha) or Ang II treatment groups. Treatment with 1/4 PGF(2alpha)/Ang II decreased plasma progesterone concentration, and induced luteolysis and oestrus. The onset of oestrus in cows treated with full-dose (500 microg) PGF(2alpha) (3.1 +/- 0.2 (mean +/- SEM) days after treatment) was significantly earlier than that in cows treated with 1/4 PGF(2alpha)/Ang II (4.8 +/- 0.2 days after treatment) (P < 0.05). The results from the present study demonstrate that an intraluteal injection of Ang II after i.m. administration of a subluteolytic dose of PGF(2alpha) analogue induces luteolysis and oestrus. Thus, these results support the contention that Ang II is directly correlated with the process of luteal regression in cows.
1 型血管紧张素-II 受体介导大鼠黄体细胞内的钙动员。
影响因子：
4.8
作者：
Pepperell,JR;Nemeth,G;Yamada,Y;Naftolin,F
通讯作者：
Naftolin,F
大鼠卵巢闭锁卵泡上血管紧张素 II 受体选择性表达的证据：放射自显影研究。
影响因子：
4.8
作者：
Daud,AI;Bumpus,FM;Husain,A
通讯作者：
Husain,A