Birth size in relation to age at menarche and adolescent body size: Implications for breast cancer risk
Birth size in relation to age at menarche and adolescent body size: Implications for breast cancer risk
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DOI：
10.1002/ijc.11103
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发表时间：
2003-06-20
影响因子：
6.4
通讯作者：
Stuver, SO
中科院分区：
文献类型：
--
作者：
Romundstad, PR;Vatten, LJ;Stuver, SO
初潮年龄和身高与患乳腺癌的风险增加有关，新证据表明，出生时的体型也与成年后患乳腺癌的风险呈正相关。我们已经探讨了这种影响是否可以通过影响初潮年龄或青春期身高来调节。对3 343名13至19岁足月出生且母亲无妊娠病史的挪威女孩的初潮年龄和青春期身高信息，分别与国家出生医学登记处记录的出生体重和身高信息联系起来。我们使用一般线性模型和Cox回归分析，将出生尺寸的五分位数（经妊娠长度调整）与初潮年龄、青少年身高和体重联系起来。在人口的子样本中，我们也有关于母亲初潮年龄的信息，以及父母双方成年后的身高和体重指数。我们探讨了父母因素是否混淆了围产期预测因子与女儿青春期结局之间的关联。我们发现初潮年龄随着出生体重的下降而提前（p = 0.03），出生时较瘦的女孩（即体重指数最低的五分位数）初潮年龄比其他女孩早（p = 0.02）。出生时的体重和身高与青春期的身高呈强烈正相关（p < 0.001），但表明出生时肥胖的ponderal指数与青春期身高呈负相关（p = 0.002）。在可获得这些信息的子样本中，调整父母身高、体重指数和母亲初潮年龄，表明这些父母因素没有实质性的混淆。我们的研究结果表明，出生尺寸与成年乳腺癌之间的正相关关系不太可能由初潮年龄介导，而可能与青春期身高增加有关。(C) 2003 Wiley-Liss, Inc。
Early age at menarche and tallness are associated with increased risk for breast cancer, and emerging evidence suggests that body size at birth also is positively associated with breast cancer risk in adulthood. We have explored whether this effect of birth size could be mediated by influencing age at menarche or body height during adolescence. Information on age at menarche and adolescent height among 3,343 Norwegian girls 13 to 19 years of age, born at term and whose mothers had no history of gestational disease was individually linked to information on birth weight and length recorded in the national Medical Birth Registry. We related quintiles of birth size, adjusted for length of gestation, to age at menarche and adolescent height and weight, using general linear modeling and Cox regression analyses. In a subsample of the population, we also had information on maternal age at menarche, as well as adult height and body mass index in both parents. We explored whether parental factors confounded the association between perinatal predictors and adolescent outcomes in the daughters. We found that age at menarche tended to occur earlier with decreasing birth weight (p for trend = 0.03), and girls who were thin at birth (i.e., in the lowest quintile of ponderal index) had an earlier age at menarche than other girls (p = 0.02). Weight and length at birth were strongly and positively related to tallness during adolescence (p for trend < 0.001), but ponderal index, indicating obesity at birth, was negatively associated with adolescent height (p for trend = 0.002). Adjustment for parental height, body mass index and maternal age at menarche, in the subsample where this information was available, indicated no substantial confounding by these parental factors. Our results suggest that a positive association between birth size and adult breast cancer is not likely to be mediated by early age at menarche, but possibly by increased body height in adolescence. (C) 2003 Wiley-Liss, Inc.