The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis
The angiotensin-I converting enzyme gene I/D variation contributes to end-stage renal disease risk in Chinese patients with type 2 diabetes receiving hemodialysis
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血管紧张素-I转换酶基因I/D变异导致接受血液透析的中国2型糖尿病患者终末期肾病风险
DOI：
10.1007/s11010-016-2819-6
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发表时间：
2016-09
影响因子：
4.3
通讯作者：
Jia, Weiping
中科院分区：
文献类型：
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作者：
Bao, Yuqian;Liu, Limei;Liu, Yanjun;Jia, Weiping
血管紧张素- 1转换酶（ACE）I/D变异的DD基因型是否与2型糖尿病（T2DM）终末期肾病（ESRD）风险有关仍存在争议。研究设计、病例和对照定义、样本量和种族的差异可能导致关联研究中报告的差异。我们进行了一项病例对照研究，以评估中国接受血液透析的T2DM患者的acei /D变异与ESRD风险的关系，并分析了基因型-表型的相互作用。无相关关系的中国患者（n= 432）分为非糖尿病肾病（DN）对照组（n= 222，糖尿病病程100 ~ 10年，无肾脏受累迹象）和DN-ESRD组（n= 210，因T2DM引起的ESRD，接受血液透析）。采用聚合酶链反应对所有432名受试者进行peacei /D基因型分析。DN-ESRD组ID + DD基因型的频率高于非dn对照组(65.2 vs 50.9%；调整OR为1.98 （95% CI, 1.31-3.00；P= 0.001）。在DN-ESRD组中，与II亚组相比，DD基因型亚组的HbA1c和舒张压（DBP）显著升高（均p < 0.05）。acei /D变异的DD基因型可能与更高的血压和HbA1c升高有关，因此可以预测中国血液透析T2DM患者DN-ESRD的发生、进展和严重程度。
Whether the DD genotype of the angiotensin-I converting enzyme (ACE)I/D variation contributes to end-stage renal disease (ESRD) risk in type 2 diabetes mellitus (T2DM) remains controversial. Differences in study design, case and control definition, sample size and ethnicity may contribute to the discrepancies reported in association studies. We performed a case–control study to evaluate the association of theACEI/D variation with ESRD risk in Chinese patients with T2DM receiving hemodialysis and analyzed the genotype–phenotype interaction. Unrelated Chinese patients (n= 432) were classified into the non-diabetic nephropathy (DN) control group (n= 222, duration of diabetes >10 years, no signs of renal involvement) and the DN-ESRD group (n= 210; ESRD due to T2DM, receiving hemodialysis). Polymerase chain reaction was used to genotypeACEI/D for all 432 subjects. The frequencies of the ID + DD genotypes were higher in the DN-ESRD group than non-DN control group (65.2 vs. 50.9 %; adjusted OR 1.98 (95 % CI, 1.31–3.00;P= 0.001). In the DN-ESRD group, the DD genotypic subgroup had significantly elevated HbA1c and diastolic blood pressure (DBP) compared to the II subgroup (bothP< 0.05). The DD genotype of theACEI/D variation may be associated with more elevated blood pressure and HbA1c, and therefore may predict the development, progression and severity of DN-ESRD in Chinese patients with T2DM undergoing hemodialysis.
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影响因子：
6.1
作者：
Oh, Se Won;Kim, Yong Chul;Chin, Ho Jun
通讯作者：
Chin, Ho Jun
影响因子：
3.5
作者：
F. Cambien
通讯作者：
F. Cambien
DOI：
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发表时间：
2001-03
期刊：
JOP : Journal of the pancreas
影响因子：
--
作者：
V. Viswanathan;Y. Zhu;K. Bala;S. Dunn;C. Snehalatha;Ambady Ramachandran;M. Jayaraman;K. Sharma
通讯作者：
V. Viswanathan;Y. Zhu;K. Bala;S. Dunn;C. Snehalatha;Ambady Ramachandran;M. Jayaraman;K. Sharma
影响因子：
13.2
作者：
Collins, Allan J.;Foley, Robert N.;Agodoa, Lawrence
通讯作者：
Agodoa, Lawrence
影响因子：
16.2
作者：
通讯作者：
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