Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study.
Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study.
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DOI：
10.1136/bmjopen-2014-004877
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发表时间：
2014-03-21
期刊：
影响因子：
2.9
通讯作者：
Stronks K
中科院分区：
文献类型：
--
作者：
Agyemang C;Beune E;Meeks K;Owusu-Dabo E;Agyei-Baffour P;Aikins Ad;Dodoo F;Smeeth L;Addo J;Mockenhaupt FP;Amoah SK;Schulze MB;Danquah I;Spranger J;Nicolaou M;Klipstein-Grobusch K;Burr T;Henneman P;Mannens MM;van Straalen JP;Bahendeka S;Zwinderman AH;Kunst AE;Stronks K
与欧洲裔人口相比，肥胖和2型糖尿病(T2D)在非洲移民中非常普遍。潜在的原因仍然是一个谜。基因-环境相互作用现在被认为是导致肥胖症和T2D高发的一个潜在的合理因素，但尚未被调查。非洲移民肥胖和糖尿病研究(RODAM)项目的总体目的是通过(1)研究环境(如生活方式)、医疗保健、生化和(EPI)遗传因素之间的复杂相互作用及其对肥胖和T2D高患病率的相对贡献，了解散居国外的撒哈拉以南非洲人肥胖和T2D高发的原因；(2)确定这些大类中的具体风险因素，以指导干预计划；以及(3)为改进诊断和治疗提供基本知识。罗达姆是一项多中心横断面研究，研究对象是撒哈拉以南非洲同质的参与者(即加纳人)，年龄25岁，生活在加纳、荷兰、德国和英国的城乡(http://rod-am.eu/).)。在所有地点收集关于主要结果、遗传和非遗传因素的标准化数据。其目标是从每个地点招募6250人，包括5个小组，每组1250人。在加纳，库马西和奥布阿西(城市阶层)和阿散蒂地区的村庄(农村阶层)被用作招募地点。在欧洲，加纳移民是通过市政当局或加纳组织登记来挑选的。所有的网站都获得了伦理上的批准。本文概述了本研究的理论基础、概念框架和研究方法。不同地区的差异将使我们能够深入了解导致肥胖和T2D发生的遗传和非遗传因素，并将为有针对性的干预和预防计划提供信息，并为改善这些人群和其他人群的诊断和治疗提供基础。
Obesity and type 2 diabetes (T2D) are highly prevalent among African migrants compared with European descent populations. The underlying reasons still remain a puzzle. Gene–environmental interaction is now seen as a potential plausible factor contributing to the high prevalence of obesity and T2D, but has not yet been investigated. The overall aim of the Research on Obesity and Diabetes among African Migrants (RODAM) project is to understand the reasons for the high prevalence of obesity and T2D among sub-Saharan Africans in diaspora by (1) studying the complex interplay between environment (eg, lifestyle), healthcare, biochemical and (epi)genetic factors, and their relative contributions to the high prevalence of obesity and T2D; (2) to identify specific risk factors within these broad categories to guide intervention programmes and (3) to provide a basic knowledge for improving diagnosis and treatment. RODAM is a multicentre cross-sectional study among homogenous sub-Saharan African participants (ie, Ghanaians) aged >25 years living in rural and urban Ghana, the Netherlands, Germany and the UK (http://rod-am.eu/). Standardised data on the main outcomes, genetic and non-genetic factors are collected in all locations. The aim is to recruit 6250 individuals comprising five subgroups of 1250 individuals from each site. In Ghana, Kumasi and Obuasi (urban stratum) and villages in the Ashanti region (rural stratum) are served as recruitment sites. In Europe, Ghanaian migrants are selected through the municipality or Ghanaian organisations registers. Ethical approval has been obtained in all sites. This paper gives an overview of the rationale, conceptual framework and methods of the study. The differences across locations will allow us to gain insight into genetic and non-genetic factors contributing to the occurrence of obesity and T2D and will inform targeted intervention and prevention programmes, and provide the basis for improving diagnosis and treatment in these populations and beyond.
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影响因子：
5.1
作者：
Amoah, AGB;Owusu, SK;Adjei, S
通讯作者：
Adjei, S
影响因子：
3.2
作者：
Agyemang, Charles;Owusu-Dabo, Ellis;Stronks, Karien
通讯作者：
Stronks, Karien
影响因子：
5.4
作者：
Agyemang, Charles;Kunst, Anton E.;Stronks, Karien
通讯作者：
Stronks, Karien
影响因子：
7
作者：
Kroenke, Kurt;Spitzer, Robert L.;Loewe, Bernd
通讯作者：
Loewe, Bernd
影响因子：
120.7
作者：
Karter, AJ;Ferrara, A;Selby, JV
通讯作者：
Selby, JV