"One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer
"One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer
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“One-for-AII”型、可生物降解的普鲁士蓝/二氧化锰杂化纳米晶，用于乳腺癌的三模态成像引导光热治疗和氧调节
DOI：
10.1021/acsami.7b01365
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发表时间：
2017-04-26
影响因子：
9.5
通讯作者：
Qian, Zhiyong
中科院分区：
文献类型：
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作者：
Peng, Jinrong;Dong, Mingling;Qian, Zhiyong
多结节成像引导的诊断和治疗已成为纳米诊断材料领域的热点。为了提供更合适的治疗诊断学候选者。采用一锅法制备了粒径小于50 nm的普鲁士蓝（PB）/二氧化锰（MiO（2））杂化纳米粒子（PBMn）。由KMnO_4还原而成的MnO_2不仅控制了PB的粒径、光学性质和横向弛豫速率（r（2）），而且提高了PB对H_2 O_2的催化产氧效率。PBMn可作为光声成像（派）和纵向弛豫（T-1）模式磁共振成像造影剂（分别为生理盐水处理组的14倍和1.8倍）。注射PBMn可使肿瘤组织氧分压由2.1 ± 0.2 kPa调整至9.3 ± 0.4 kPa，并使肿瘤内氧合血红蛋白与还原血红蛋白的比值发生改变，有利于抗磁T_2加权像（T_2WI）信号增强（约为生理盐水组的2倍）。此外，PBMn介导的PTT可以在体外和体内有效地抑制MCF-7肿瘤的生长。PBMn可用作派/T-1/T-2三峰造影剂，用于成像引导的PTT，以及用于外移植乳腺癌的氧调节。
Multiinodal imaging-guided diagnosis arid therapy has been highlighted in the area of theranostic nanomaterials. To proivide more suitable theranostic candidates,. Prussian blue (PB)/manganesedioxide (MiO(2))hybrid nanoparticles (PBMn) smaller than 50 nm are prepared by a one-pot method. MnO2, which is reduced from KMnO4:, not only controls the particle size, the optical properties, and the transverse relaxation rate (r(2)) = of PB but also enhances the catalysis efficacy of,PB to H2O2 for oxygen generation. PBMn can serve as a photoacoustic imaging (PAI) and longitudinal relaxation (T-1) mode magnetic resonance imaging contrast agent (14 times and 1.8 times of the saline-treated group, respectively). Injection of PBMn can regulate the, oxygen partial pressure of the tumor tissue from 2.1 +/- 0.2 to 9.3 +/- 0.4 kPa and rearrange the ratio: of oxygenated hemoglobin and deoxygenate hemoglobin:inside the tumor, which favor the enhancement of the diamagnetic T-2-weighted imaging (T2WI) signal intensity (two times that of the saline-treated group). Furthermore, PBMn-mediated PTT can efficiently inhibit the growth of the MCF-7 tumor in vitro and in vivo. PBMn can serve as a PAI/T-1/T-2 trimodal contrast agent and in imaging-guided PTT, as well as in the oxygen regulation of the exografted breast cancer.