Androgens and mood dysfunction in women: Comparison of women with polycystic ovarian syndrome to healthy controls
Androgens and mood dysfunction in women: Comparison of women with polycystic ovarian syndrome to healthy controls
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DOI：
10.1097/01.psy.0000127871.46309.fe
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发表时间：
2004-05-01
影响因子：
3.3
通讯作者：
Ehrmann, DA
中科院分区：
文献类型：
--
作者：
Weiner, CL;Primeau, M;Ehrmann, DA
目的：我们对人类性腺激素对行为的组织和激活作用的理解依赖于对内分泌失调的研究。多囊卵巢综合征（PCOS）是一种激素紊乱，始于青春期，其特征是游离睾酮（FT）水平长期升高。本研究的目的是：1）比较PCOS女性的消极情绪状态与激素水平正常的女性，2）检查消极情绪与雄激素之间的关系。研究方法：27名PCOS患者与27名体重指数正常的女性进行病例匹配，因为超重是PCOS的常见症状，可能会影响情绪状态。测定血清FT、总睾酮、性激素结合球蛋白、雌二醇和孕酮水平。自我报告的抑郁，愤怒，焦虑和攻击性进行了分析组之间，并比较各组的激素值的个人得分。结果如下：在PCOS组中抑郁症显著增加，并且在考虑与身体机能和其他情绪状态相关的变量后仍然如此。此外，FT和负性情绪之间的曲线关系跨组建议：最高的负性情绪量表分数与FT值刚刚超过正常上限，而较低的负性情绪水平对应于正常和极高的FT值。结论：这些结果与睾酮对成年女性行为的激活影响模型一致。对未来的研究和治疗PCOS和其他更年期情绪障碍的影响进行了讨论。
Objective: Our understanding of the organizational and activational effects of human gonadal hormones on behavior has depended on the study of endocrine disorders. Polycystic ovarian syndrome (PCOS) is a hormonal disorder that begins in puberty and is characterized by chronically augmented free testosterone (FT) levels. The purposes of this study were 1) to compare negative mood states of women with PCOS to those of women with normal hormonal levels and 2) to examine the relationship between negative moods and androgens. Methods: Twenty-seven women with PCOS were case-matched to 27 normal menstruating women on body mass index since being over-weight is a common symptom of PCOS and could affect mood states. Serum levels of FT, total testosterone, sex hormone binding globulin, estradiol, and progesterone were determined. Self-reported depression, anger, anxiety, and aggression were analyzed between groups, and individual scores were compared across groups to hormone values. Results: Depression was significantly increased in the PCOS group and remained so after considering the variance related to physical symptomatology and other mood states. Furthermore, a curvilinear relationship between FT and negative affect across groups was suggested: the most elevated negative mood-scale scores were associated with FT values just beyond the upper limits of normal, while lower negative mood levels corresponded to both normal and extremely high values of FT. Conclusions: These results are consistent with a model of activational influences of testosterone on adult female behavior. Implications are discussed for future research and for treatment of PCOS and other menstrual-cycle mood disorders.