Temporal dynamic of neural mechanisms involved in empathy for pain: An event-related brain potential study
Temporal dynamic of neural mechanisms involved in empathy for pain: An event-related brain potential study
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DOI：
10.1016/j.neuropsychologia.2007.07.023
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发表时间：
2008-01-01
期刊：
影响因子：
2.6
通讯作者：
Han, Shihui
中科院分区：
文献类型：
--
作者：
Fan, Yan;Han, Shihui
以前的神经影像学研究已经确定了一个神经回路，涉及对疼痛的同情。然而，移情过程背后的神经活动的时间动力学仍然知之甚少。当前的研究通过记录健康成年人的事件相关脑电位（ERPs）来研究这一点，这些成年人看到了处于痛苦或中性情况的手的图片或卡通。受试者进行疼痛判断任务，需要注意的疼痛线索的刺激或计数任务，撤回他们的注意力从这些线索。ERP结果显示，感觉刺激后140 ms，额叶疼痛和中性刺激之间的早期分化。长潜伏期共情反应后380毫秒观察到的中央顶叶区域，更突出的左半球比右半球。早期和晚期共情反应，分别调制的情境现实的刺激和自上而下的注意疼痛线索。此外，在140-180毫秒的平均ERP幅度与主观报告的程度感知他人的痛苦和自我不愉快。ERP结果支持一个模型的同理心的痛苦，包括早期的情感分享和后期的认知评价。(C)2007爱思唯尔有限公司版权所有。
Previous neuroimaging studies have identified a neural circuit that is involved in empathy for pain. However, the temporal dynamics of neural activities underlying empathic processes remains poorly understood. This was investigated in the current study by recording event-related brain potentials (ERPs) from healthy adults who were presented with pictures or cartoons of hands that were in painful or neutral situations. Subjects performed a pain judgment task that required attention to pain cues in the stimuli or a counting task that withdrew their attention from these cues. The ERP results showed early differentiation between painful and neutral stimuli over the frontal lobe at 140 ms after sensory stimulation. A long-latency empathic response was observed after 380 ms over the central-parietal regions and was more salient over the left than right hemispheres. The early and late empathic responses were, respectively, modulated by contextual reality of stimuli and by top-down attention to the pain cues. Moreover, the mean ERP amplitudes at 140-180 ms were correlated with subjective reports of the degree of perceived pain of others and of self-unpleasantness. The ERP results support a model of empathy for pain consisting of early emotional sharing and late cognitive evaluation. (C) 2007 Elsevier Ltd. All rights reserved.