Structural Characteristics and In Vitro Biodegradation of a Novel Zn-Li Alloy Prepared by Induction Melting and Hot Rolling
Structural Characteristics and In Vitro Biodegradation of a Novel Zn-Li Alloy Prepared by Induction Melting and Hot Rolling
复制标题
DOI：
10.1007/s11661-016-3901-0
复制
发表时间：
2017-03-01
影响因子：
2.8
通讯作者：
Drelich, Jaroslaw W.
中科院分区：
文献类型：
--
作者：
Zhao, Shan;McNamara, Cameron T.;Drelich, Jaroslaw W.
锌作为生物可吸收金属显示出很大的前景;然而，纯锌的低拉伸强度限制了其用于血管内支架目的的应用。在本研究中，一种新的Zn-xLi合金（x = 2，4，6 at. PCT）通过在氩气气氛中感应熔融制备并通过热轧处理。通过X射线衍射和光学显微镜对二元合金的结构进行了表征。力学测试表明，Li掺入Zn中使极限拉伸强度从< 120 MPa（纯Zn）增加到> 560 MPa（x = 6 at. pct）。通过在模拟体液中的浸泡试验评价了体外腐蚀行为。Zn-2Li和Zn-4Li腐蚀研究表明，腐蚀速率和产物与体内纯Zn观察到的相似，此外，Zn-4Li合金比Zn-2Li具有更高的耐腐蚀性。本文的发现鼓励进一步探索Zn-Li系统在生物医学血管支持应用中的结构用途，最终目标是简化支架手术，从而减少支架相关并发症。
Zinc shows great promise as a bioabsorbable metal; however, the low tensile strength of pure zinc limits its application for endovascular stent purposes. In this study, a new Zn-xLi alloy (with x = 2, 4, 6 at. pct) was prepared by induction melting in an argon atmosphere and processed through hot rolling. Structures of the formulated binary alloys were characterized by X-ray diffraction and optical microscopy. Mechanical testing showed that the incorporation of Li into Zn increased ultimate tensile strength from < 120 MPa (pure Zn) to > 560 MPa (x = 6 at. pct). In vitro corrosion behavior was evaluated by immersion tests in simulated body fluid. The Zn-2Li and Zn-4Li corrosion study demonstrated that corrosion rates and products resemble those observed for pure Zn in vivo, and in addition, the Zn-4Li alloy exhibits higher resistance to corrosion as compared to Zn-2Li. The findings herein encourage further exploration of Zn-Li systems for structural use in biomedical vascular support applications with the ultimate goal of simplifying stent procedures, thereby reducing stent-related complications.