A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.
A defect of immunoregulatory T cell subsets in systemic lupus erythematosus patients demonstrated with anti-2H4 antibody.
复制标题
抗 2H4 抗体证实系统性红斑狼疮患者免疫调节 T 细胞亚群存在缺陷。
DOI：
10.1172/jci112882
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Schlossman,SF
中科院分区：
文献类型：
--
作者：
Morimoto,C;Steinberg,AD;Letvin,NL;Hagan,M;Takeuchi,T;Daley,J;Levine,H;Schlossman,SF
系统性红斑狼疮（SLE）患者外周血淋巴细胞（PBL）的细胞表面表型用抗2h4单克隆抗体表征，该抗体定义了人抑制诱导剂亚群。T4+2H4+细胞群已被证明对T8+抑制细胞的激活至关重要。与正常对照（21 +/- 1%）相比，SLE患者PBL中T4+2H4+细胞的百分比（13 +/- 2%）显著降低（P < 0.001）。这种减少在活动性SLE患者中最大，特别是那些有肾脏疾病的患者。对SLE和肾脏疾病患者的系列分析显示，循环T4+2H4+细胞阳性百分比与疾病活动性之间存在相关性。此外，SLE患者自身混合淋巴细胞反应激活的T4+细胞中T4+2H4+细胞百分比低与抑制诱导剂功能下降有显著相关性。因此，活动性肾脏疾病的SLE患者存在T4+2H4+抑制诱导剂T细胞亚群的缺乏。
The cell surface phenotype of peripheral blood lymphocytes (PBL) of systemic lupus erythematosus (SLE) patients was characterized with the anti-2H4 monoclonal antibody that defines the human suppressor inducer subset. The T4+2H4+ population of cells has been shown to be critical for the activation of T8+ suppressor cells. Patients with SLE has a markedly decreased percentage of T4+2H4+ cells (13 +/- 2%) in their PBL compared with normal controls (21 +/- 1%) (P less than 0.001). This reduction was greatest in patients with active SLE, especially those with renal disease. Serial analysis of patients with SLE and renal disease showed a correlation between percent positive circulating T4+2H4+ cells and disease activity. Moreover, there was a significant correlation between a low percentage of T4+2H4+ cells and decreased suppressor-inducer function in autologous mixed lymphocyte reaction-activated T4+ cells from SLE patients. Thus, a deficiency exists in SLE patients with active renal disease in the T4+2H4+ suppressor-inducer T cell subset.