Modeling of adhesion, protrusion, and contraction coordination for cell migration simulations.
Modeling of adhesion, protrusion, and contraction coordination for cell migration simulations.
复制标题
细胞迁移模拟的粘附、突出和收缩协调建模。
DOI：
10.1007/s00285-012-0634-6
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发表时间：
2014
影响因子：
1.9
通讯作者：
Zaman,MH
中科院分区：
文献类型：
--
作者：
Sakamoto,Y;Prudhomme,S;Zaman,MH
细胞迁移是一种高度复杂的动态生物学现象，它涉及细胞粘附、突起和收缩等独特子过程的精确时空协调。个体肿瘤细胞迁移的观察揭示，细胞通常在类似天然环境中表现出间充质型或变形虫型迁移模式。然而，还观察到一些迁移细胞能够通过改变其迁移类型在形态上适应其环境。最近的研究表明，事实上，肿瘤细胞的生物物理和生物力学特性的变化可以可逆地控制它们从一种迁移类型向另一种迁移类型的转变。这些变化可能是由内部细胞生物力学机制以及细胞外基质的机械和拓扑特性引起的。为了理解这两种模式之间的复杂过渡和迁移过程中细胞内部力学所起的作用，我们开发了一种新的轴对称超粘弹性细胞模型来模拟迁移细胞的动力学行为。从我们的研究的数值结果定量地表明，细胞的生物力学性能可能发挥重要作用，在迁移过程中的变形虫间充质转化。因此，我们的研究不仅有助于创建一个模拟细胞过程的新平台，而且还将为亚细胞机制在肿瘤侵袭和转移过程中调节各种迁移模式的作用提供见解。
Cell migration is a highly complex, dynamical biological phenomenon that involves precise spatio-temporal coordination of distinctive sub-processes including adhesion, protrusion, and contraction of the cell. Observations of individual tumor cell migration reveal that cells generally exhibit either mesenchymal-type or amoeboid-type migration modes in native like environments. However, it has also been observed that some migrating cells are capable of morphologically adapting to their environment by modifying their type of migration. Recent studies suggest in fact that changes in biophysical and biomechanical properties of tumor cells can reversibly control their transition from one type of migration to the other. These changes may be caused by internal cell biomechanical mechanisms as well as mechanical and topological properties of the extracellular matrix. In order to understand the complex transition between the two modes and the role played by internal cellular mechanics during migration, we have developed a novel axisymmetric hyperviscoelastic cell model to simulate the dynamical behavior of a migrating cell. Numerical results from our study quantitatively demonstrate that the biomechanical properties of the cell may play an important role in the amoeboid-mesenchymal transition during migration. Our study will therefore not only help in creating a new platform for simulating cellular processes but will also provide insights into the role of sub-cellular mechanics in regulating various modes of migration during tumor invasion and metastasis.