Role of osteopontin in heart failure associated with aging.
Role of osteopontin in heart failure associated with aging.
复制标题
骨桥蛋白在与衰老相关的心力衰竭中的作用。
DOI：
10.1007/s10741-010-9158-6
复制
发表时间：
2010
影响因子：
4.6
通讯作者：
Singh,Krishna
中科院分区：
文献类型：
--
作者：
Singh,Mahipal;Foster,CerroneR;Dalal,Suman;Singh,Krishna
心血管疾病是老年人死亡的主要原因之一。许多老年人的发病率和死亡率可归因于急性缺血事件导致心肌梗死（MI）和心肌细胞死亡。已有证据表明，衰老与心肌梗死后的不良重构相关，表现为心肌修复效果较差、梗死扩张加剧和间隔肥大。骨桥蛋白（osteopontin， OPN）在心肌梗死后的心脏中表达增加。转基因小鼠研究表明，OPN表达增加通过调节胶原沉积和纤维化在心肌梗死后左室重构中发挥保护作用。OPN是一种多功能蛋白，具有影响与梗死愈合相关的分子和细胞变化的潜力。心肌梗死后的愈合过程包括以下几个暂时重叠的阶段：(1)伴有中性粒细胞和巨噬细胞迁移和粘附的炎症、吞噬和炎症基因表达；(2)组织修复，包括成纤维细胞粘附和增殖、肌成纤维细胞分化、细胞外基质沉积和瘢痕形成；(3)心肌细胞凋亡、肥大和心肌血管生成对梗死和非梗死心肌结构和功能的重塑。本文就心肌梗死后心肌组织中OPN的表达及其在梗死愈合各阶段的作用进行综述。
Cardiovascular disease is one of the leading causes of death in the elderly. Much of the morbidity and mortality in the elderly is attributable to acute ischemic events leading to myocardial infarction (MI) and death of cardiac myocytes. Evidence has been provided that aging associated with adverse remodeling post MI as demonstrated by less effective myocardial repair, greater infarct expansion, and septal hypertrophy. Expression of osteopontin (OPN) increases in the heart post MI. Transgenic mice studies suggest that increased expression of OPN plays a protective role in post-MI LV remodeling by modulating collagen deposition and fibrosis. OPN, a multifunctional protein, has the potential to influence the molecular and cellular changes associated with infarct healing. The post-MI infarct healing process involves temporarily overlapping phases that include the following—(1) inflammation with migration and adhesion of neutrophils and macrophages, phagocytosis and inflammatory gene expression; (2) tissue repair with fibroblast adhesion and proliferation, myofibroblast differentiation, extracellular matrix deposition and scar formation; and (3) structural and functional remodeling of infarcted and non-infarcted myocardium through cardiac myocyte apoptosis, hypertrophy and myocardial angiogenesis. This review is focused on the expression of OPN in the heart post MI and its role in various phases of infarct healing.