Contribution of nitric oxide to adaptation of tibetan sheep to high altitude
Contribution of nitric oxide to adaptation of tibetan sheep to high altitude
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DOI：
10.1016/j.resp.2003.11.005
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发表时间：
2004-05-20
影响因子：
2.3
通讯作者：
Wang, XQ
中科院分区：
文献类型：
--
作者：
Koizumi, T;Ruan, ZH;Wang, XQ
我们研究了内源性一氧化氮合酶（NOS）抑制对低海拔和高海拔清醒绵羊肺血流动力学的影响，以评估NO在适应低氧环境中的作用。在日本松本（海拔680 m）、中国兴（海拔2300 m）和中国马新（海拔3750 m） 3个地方制备未麻醉的公羊，测定NOS抑制前后的肺动脉（Ppa）和肺血管阻力（PVR）。采用非选择性NOS抑制剂n- w-硝基- l -精氨酸（NLA, 20 mg/kg）。基线Ppa随着海拔的升高而升高。NLA给药后，各组动物PVR均显著升高。(C) 2003 Elsevier B.V.版权所有
We examined the effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary hemodynamics in awake sheep living at low and high altitudes to evaluate the role of NO in adaptation to an hypoxic environment. Unanaesthetized male sheep in three places-Matsumoto, Japan (680 m above sea level), Xing, China (2300 m) and Maxin, China (3750 m)-were prepared for measurements of pulmonary artery (Ppa) and pulmonary vascular resistance (PVR) before and after the NOS inhibition. The non-selective NOS inhibitor, N-w-nitrO-L-argine (NLA, 20 mg/kg) was used. Baseline Ppa became elevated with an increase in altitude. After NLA administration, PVR significantly increased in animals of all groups. However, the increase in PVR after NLA in tibetan sheep at 3750 m was significantly higher than those in other groups. We conclude that augmented endogenous NO production may contribute to regulating the pulmonary vascular tone in tibetan sheep (3750 m) adapted to high altitude. (C) 2003 Elsevier B.V. All rights reserved.