Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases
Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases
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DOI：
10.3109/08820139.2013.822389
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发表时间：
2014-01-01
影响因子：
2.8
通讯作者：
Zhou, Rong
中科院分区：
文献类型：
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作者：
Yang, Yan;Zhang, Kui;Zhou, Rong
有研究表明，前体miRNA的rs 2910164和rs3746444多态性与自身免疫性疾病（AD）的风险显著相关，被描述为候选易感因素，然而结果产生了相互矛盾的发现。我们进行了这项荟萃分析，以探讨这两个多态性是否有助于通过使用等位基因比较和不同的遗传模型，对AD的易感性，我们还进行了分层分析的种族和疾病表型。我们的荟萃分析显示，在亚洲人群中，SNP rs 2910164的GC基因型与AD的风险增加显著相关;在其他疾病亚组中，GC基因型的OR分别高于GG+CC基因型（OR = 0.89，95%CI = 0.79-0.99; OR = 0.84，95%CI = 0.75-0.95）。此外，与TT和TT+TC携带者相比，发现rs3746444的CC基因型与AD风险升高相关（OR = 0.55，95%CI = 0.34-0.90; OR = 0.59，95%CI = 0.36-0.97）。总而言之，这些发现表明rs 2910164和rs3746444多态性可能在AD的发病机制中发挥潜在作用。
It has been suggested that the rs2910164 and rs3746444 polymorphisms of pre-miRNA are significantly associated with the risk of autoimmune diseases (ADs), described as candidate susceptibility factors, whereas results have yield conflicting findings. We conducted this meta-analysis to investigate whether these two polymorphisms contribute to susceptibility to ADs by using allele comparison and different genetic models, and we also performed stratified analyses by ethnicity and disease phenotype. Our meta-analysis demonstrated that increased risk of ADs was significantly associated with GC genotype in Asians for SNP rs2910164 in the stratified analyses by ethnicity; there was increased OR for GC genotype compared with that for GG+CC genotype in other disease subgroup, respectively (OR = 0.89, 95% CI = 0.79-0.99; OR = 0.84, 95% CI = 0.75-0.95, respectively). Moreover, elevated AD risk was found to be associated with CC genotype of rs3746444 in contrast to TT and TT+TC carriers, respectively (OR = 0.55, 95% CI = 0.34-0.90; OR = 0.59, 95% CI = 0.36-0.97, respectively). Taken together, these findings indicated that the rs2910164 and rs3746444 polymorphisms may play potential roles in the pathogenesis of ADs.