Gonadotropin-induced desensitization of epinephrine action in the luteinized rat ovary.
Gonadotropin-induced desensitization of epinephrine action in the luteinized rat ovary.
复制标题
促性腺激素诱导黄素化大鼠卵巢中肾上腺素作用的脱敏。
DOI：
10.1210/endo-107-1-280
复制
发表时间：
1980
期刊：
影响因子：
4.8
通讯作者：
K. Catt
中科院分区：
文献类型：
--
作者：
J. P. Harwood;N. Richert;M. Dufau;K. Catt
在黄体化的大鼠卵巢中，研究了肾上腺素对黄体细胞功能的作用，以及促性腺激素诱导的黄体脱敏对β - 肾上腺素能反应的影响。肾上腺素和LH均刺激卵巢匀浆中的腺苷酸环化酶活性，并增加黄体细胞中cAMP和孕酮的产生。两种激素的最大有效剂量对腺苷酸环化酶活性或类固醇生成没有累加效应。普萘洛尔可抑制肾上腺素对腺苷酸环化酶和孕酮产生的作用，但酚妥拉明则无此作用，且两种肾上腺素能拮抗剂均不影响LH的作用。这些结果表明，LH和β - 肾上腺素能效应物通过独立的受体作用于共同的腺苷酸环化酶库，以刺激黄体细胞中孕酮的产生。在用脱敏剂量的hCG处理的大鼠卵巢中，LH/hCG刺激腺苷酸环化酶活性的能力下降，同时伴有短暂的……
The actions of epinephrine on luteal cell function, and the effects of gonadotropin-induced luteal desensitization upon β-adrenergic responses, were examined in the luteinized rat ovary. Both epinephrine and LH stimulated adenylate cyclase activity in ovarian homogenates and increased the production of cAMP and progesterone in luteal cells. Maximally effective doses of the two hormones did not have an additive effect upon adenylate cyclase activity or steroidogenesis. The actions of epinephrine on adenylate cyclase and progesterone production were inhibited by propranolol but not by phentolamine, and neither adrenergic antagonist influenced the actions of LH. These results indicate that LH and β-adrenergic effectors act through independent receptors on a common pool of adenylate cyclase to stimulate progesterone production in the luteal cell. In ovaries from rats treated with desensitizing doses of hCG, the decreased ability of LH/hCG to stimulate adenylate cyclase activity was accompanied by a transient ...