Exercise Science and Child Health: A Tale of Many Journeys.
Exercise Science and Child Health: A Tale of Many Journeys.
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运动科学与儿童健康：许多旅程的故事。
DOI：
10.1123/pes.2018-0259
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发表时间：
2019
影响因子：
1.8
通讯作者：
Cooper,DanM
中科院分区：
文献类型：
--
作者：
Cooper,DanM
儿童是身体最活跃的人；身体活动减少是儿童疾病的一个主要迹象，运动测试提供了对健康和疾病的机制洞察，而这些在孩子休息时往往是隐藏的。缺乏身体活动的流行正在导致儿童疾病风险增加，并最终以前所未有的方式增加成年人的疾病风险。心肺运动测试 (CPET) 生物标志物用于评估各种儿童疾病和病症的疾病严重程度、进展以及对治疗的反应。越来越多的数据表明，儿童的健康状况会贯穿整个生命周期，并可能被证明是晚年心血管疾病风险的一个早期、可修改的指标。尽管存在这些因素，CPET 仍未能兑现其在儿童健康研究和临床实践中的承诺。在儿童中更准确和有效地临床使用 CPET 的一个主要障碍是数据分析和测试协议未能跟上支持技术和计算能力的步伐。因此，健康和身体活动的生物标志物尚未广泛纳入儿童健康的转化研究和临床实践中。在这篇综述中，作者重新审视了一些长期以来对儿童形成 CPET 的假设。特别是，作者认为，当前主要依赖于最大运动量的测试策略可能会无意中混淆可以从更全面的数据分析中收集到的新颖的、临床上有用的见解。新的发现途径可能源于这样一个简单的认识：人类应对运动挑战所进行的生理旅程可能比最大或峰值努力的难以捉摸的目的地重要得多。
Children are the most naturally physically active human beings; reduced physical activity is a cardinal sign of childhood disease, and exercise testing provides mechanistic insights into health and disease that are often hidden when the child is at rest. The physical inactivity epidemic is leading to increased disease risk in children and, eventually, in adults in unprecedented ways. Cardiopulmonary exercise testing (CPET) biomarkers are used to assess disease severity, progress, and response to therapy across an expanding range of childhood diseases and conditions. There is mounting data that fitness in children tracks across the life span and may prove to be an early, modifiable indicator of cardiovascular disease risk later in life. Despite these factors, CPET has failed to fulfill its promise in child health research and clinical practice. A major barrier to more accurate and effective clinical use of CPET in children is that data analytics and testing protocols have failed to keep pace with enabling technologies and computing capacity. As a consequence, biomarkers of fitness and physical activity have yet to be widely incorporated into translational research and clinical practice in child health. In this review, the author re-examines some of the long-held assumptions that mold CPET in children. In particular, the author suggests that current testing strategies that rely predominantly on maximal exercise may, inadvertently, obfuscate novel and clinically useful insights that can be gleaned from more comprehensive data analytics. New pathways to discovery may emanate from the simple recognition that the physiological journey that human beings undertake in response to the challenge of exercise may be far more important than the elusive destination of maximal or peak effort.
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影响因子：
2.7
作者：
Jang Y;Kim S;Kim K;Lee D
通讯作者：
Lee D
DOI：
10.1056/nejmoa1309753
发表时间：
2014-01-30
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cunningham SA;Kramer MR;Narayan KM
通讯作者：
Narayan KM
Fontan 手术后儿科患者对运动的异常动态心肺反应。
影响因子：
24
作者：
W. Troutman;T. Barstow;Á. Galindo;D. Cooper
通讯作者：
D. Cooper
影响因子：
3.3
作者：
Staudenmayer, John;Pober, David;Freedson, Patty
通讯作者：
Freedson, Patty
用于测量肥胖儿童和青少年心肺健康的 HALO 次最大跑步机方案：原理研究证明。
DOI：
--
发表时间：
2012
期刊：
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
影响因子：
--
作者：
Peter G Breithaupt;K. Adamo;R. Colley
通讯作者：
R. Colley