Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical.
Mechanisms of ovotoxicity induced by environmental chemicals: 4-vinylcyclohexene diepoxide as a model chemical.
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DOI：
10.1007/978-1-4615-0667-6_8
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发表时间：
2001
影响因子：
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通讯作者：
P. Hoyer;E. Cannady;Nicole A. Kroeger;I. Sipes
中科院分区：
文献类型：
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作者：
P. Hoyer;E. Cannady;Nicole A. Kroeger;I. Sipes
女性出生时具有有限数量的未发育的原始卵泡。环境中的化学物质破坏这些卵泡中的卵母细胞会导致卵巢早衰（女性更年期提前），因为一旦被破坏，它们就无法被取代。众所周知，更年期与各种健康问题的发病率增加有关，如骨质疏松症、心血管疾病和卵巢癌。在实验室动物中，妇女暴露于具有卵毒性的化学物质（化疗剂、香烟烟雾污染物）已知与绝经期提前有关。因此，全面了解化学品诱发的卵毒性机制是一个与健康有关的问题（Hoyer和Sipes，1996年）。
Females are born with a finite number of undeveloped, primordial follicles. Environmental chemicals that destroy oocytes contained in these follicles can produce premature ovarian failure (early menopause in women) because once destroyed, they cannot be replaced. Menopause is known to be associated with an increased incidence of a variety of health problems such as osteoporosis, cardiovascular disease, and ovarian cancer. Exposure of women to chemicals that are ovotoxic in laboratory animals (chemotherapeutic agents, contaminants of cigarette smoke) is known to be associated with early menopause. Therefore, an overall understanding of mechanisms involved in chemical-induced ovotoxicity is of general health-related concern (Hoyer and Sipes, 1996).