Asymmetric Total Synthesis of (-)-MaoecrystalV
Asymmetric Total Synthesis of (-)-MaoecrystalV
复制标题
(-)-MaoecrystalV 的不对称全合成
DOI：
10.1002/asia.201500564
复制
发表时间：
2015
影响因子：
4.1
通讯作者：
Yang Zhen
中科院分区：
文献类型：
--
作者：
Zhang Wei-bin;Shao Wen-bin;Li Fu-zhuo;Gong Jian-xian;Yang Zhen
The asymmetric total synthesis of (−)‐maoecrystal V, a novel cytotoxic pentacyclicent‐kaurane diterpene, has been accomplished. Key steps of the current strategy involve an early‐stage semipinacol rearrangement reaction for the construction of the C10 quaternary stereocenter, a rhodium‐catalyzed intramolecular O−H insertion reaction, and a sequential Wessely oxidative dearomatization/intramolecular Diels–Alder reaction to forge the pentacyclic framework of maoecrystal V.
