Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression
Dermatopontin inhibits papillary thyroid cancer cell proliferation through MYC repression
复制标题
皮桥蛋白通过 MYC 抑制抑制乳头状甲状腺癌细胞增殖
DOI：
10.1016/j.mce.2018.10.021
复制
发表时间：
2019-01-15
影响因子：
4.1
通讯作者：
Li, Yanbing
中科院分区：
文献类型：
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作者：
Guo, Yan;Li, Hai;Li, Yanbing
皮桥蛋白（DPT），一种非胶原性细胞外基质成分，已被证明在几种类型的肿瘤中调节细胞增殖和侵袭。然而，DPT在细胞增殖，特别是乳头状甲状腺癌（PTC）细胞增殖中的生物学功能及其作用机制仍然未知。在这项研究中，我们检测到低DPT表达PTC，这是与较高的T分类。异位DPT表达在体外和体内均阻碍细胞增殖。此外，我们说明了DPT下调MYC，MYC又通过ERK途径靶向CDK 4，CDK 6和p21。这些结果表明，DPT通过MEK-ERK-MYC信号调节CDK 4、CDK 6和p21，从而抑制PTC增殖。
Dermatopontin (DPT), a noncollagenous extracellular matrix component, has been illustrated to regulate cellular proliferation and invasiveness in several types of neoplasms. Nevertheless, the biological functions of DPT in cell proliferation, especially papillary thyroid cancer (PTC) cell proliferation, remain unknown, as do the mechanisms underlying its effects. In this study, we detected low DPT expression in PTC, which was related to higher T classifications. Ectopic DPT expression impeded cell proliferation both in vitro and in vivo. Furthermore, we illustrated that DPT down-regulated MYC, which in turn targeted CDK4, CDK6 and p21, through the ERK pathway. These results suggest that DPT regulates CDK4, CDK6 and p21, through MEK-ERK-MYC signaling to repress PTC proliferation.