Magnetic wire traps and programmable manipulation of biological cells.
Magnetic wire traps and programmable manipulation of biological cells.
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磁力陷阱和生物细胞的可编程操纵。
DOI：
10.1103/physrevlett.103.128101
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发表时间：
2009-09-18
影响因子：
8.6
通讯作者：
Sooryakumar R
中科院分区：
文献类型：
--
作者：
Vieira G;Henighan T;Chen A;Hauser AJ;Yang FY;Chalmers JJ;Sooryakumar R
我们提出了一种多重方法，基于平台上锯齿状导线中的微观可编程磁陷阱，可同时对多个流体细胞或生物惰性磁性微/纳米颗粒施加定向力。温和的可调力不会产生损伤并保持细胞活力。该技术通过远程操纵（如操纵杆）T 淋巴细胞沿着硅表面上的所需轨迹进行演示，平均速度高达 20 μm/s。
We present a multiplex method, based on microscopic programmable magnetic traps in zigzag wires patterned on a platform, to simultaneously apply directed forces on multiple fluid-borne cells or biologically inert magnetic micro-/nano-particles. The gentle tunable forces do not produce damage and retain cell viability. The technique is demonstrated with T-lymphocyte cells remotely manipulated (a la joystick) along desired trajectories on a silicon surface with average speeds up to 20 μm/s.