Metabolic control of autophagy.
Metabolic control of autophagy.
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DOI：
10.1016/j.cell.2014.11.006
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发表时间：
2014-12-04
期刊：
影响因子：
64.5
通讯作者：
Kroemer G
中科院分区：
文献类型：
--
作者：
Galluzzi L;Pietrocola F;Levine B;Kroemer G
巨自噬（本文称为自噬）是一种进化上保守的适应不利微环境条件（包括有限的营养供应）的机制。一些与自噬机制相互作用的传感器已经进化到可以检测关键代谢参数的波动。在这些传感器下游运行的信号转导级联高度互连，以控制空间和时间上协调的自噬反应，从而维持单个细胞的健康和功能，同时保持有机体内平衡。在这里，我们讨论代谢回路对自噬的生理调节，以及疾病中这种控制的改变。
Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconnected to control a spatially and chronologically coordinated autophagic response that maintains the health and function of individual cells while preserving organismal homeostasis. Here, we discuss the physiological regulation of autophagy by metabolic circuitries, as well as alterations of such control in disease.