In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent.
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DOI：
10.1016/j.bmcl.2004.03.066
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发表时间：
2004-06
影响因子：
2.7
通讯作者：
Tatsuhiro Yamamoto;Kenjiro Ikuta;K. Oi;K. Abe;T. Uwatoku;F. Hyodo;M. Murata;Noboru Shigetani;K. Yoshimitsu;H. Shimokawa;H. Utsumi;Y. Katayama
中科院分区：
文献类型：
--
作者：
Tatsuhiro Yamamoto;Kenjiro Ikuta;K. Oi;K. Abe;T. Uwatoku;F. Hyodo;M. Murata;Noboru Shigetani;K. Yoshimitsu;H. Shimokawa;H. Utsumi;Y. Katayama
A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.
