Studies on hyperlymphoid mice.
Studies on hyperlymphoid mice.
复制标题
对淋巴过多小鼠的研究。
作者：
V. Wallis;E. Leuchars;M. Chaudhuri;A. Davies
将同基因但染色体可区分的淋巴结或脾脏细胞注射到成年小鼠体内，可导致T淋巴细胞和b淋巴细胞嵌合。脾脏注射小鼠也建立了造血嵌合。似乎供体T淋巴细胞被添加到宿主循环T细胞池中，从而产生了高淋巴状态。供体T淋巴细胞的百分比在正常小鼠中下降非常缓慢，但在成年胸腺切除动物中保持稳定。没有证据表明体内平衡机制涉及破坏多余的外周T淋巴细胞或严重影响T淋巴细胞从胸腺流入再循环的T细胞池。提出了t淋巴细胞系统的初步模型。
Injection of syngeneic, but chromosomally distinguishable, lymph node or spleen cells into adult mice resulted in both T- and B-lymphocyte chimaerism. In spleen-injected mice haematopoietic chimaerism was also established. It appeared that the donor T lymphocytes were added to the host recirculating T-cell pool so that a hyperlymphoid state was produced. The percentage of donor T lymphocytes declined very slowly in normal mice, but remained stable in adult-thymectomized animals. There was no evidence of a homeostatic mechanism involving destruction of excess peripheral T lymphocytes or grossly affecting the flow of T lymphocytes from the thymus into the recirculating T-cell pool. A preliminary model of the T-lymphocyte system is proposed.