Spinothalamic lamina I neurones selectively responsive to cutaneous warming in cats
Spinothalamic lamina I neurones selectively responsive to cutaneous warming in cats
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DOI：
10.1111/j.1469-7793.2001.00489.x
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发表时间：
2001-12-01
影响因子：
5.5
通讯作者：
Craig, AD
中科院分区：
文献类型：
--
作者：
Andrew, D;Craig, AD
1. 为了进一步表征I层作为中枢上升神经通路的作用，我们对麻醉猫进行了实验，以确定暖特异性腰骶脊丘脑I层神经元的定量反应特征。我们从474个神经元中鉴定出10个被皮肤加热（温暖细胞）选择性兴奋的神经元。他们的阈值都在35-37度范围内，基线为34.5度，他们的放电线性编码了分级的温度，无害的变暖刺激的灵敏度为2.1赫兹度（-1）3。温暖细胞的刺激反应功能在有害温度范围内趋于稳定。通过外周输入、中枢传导速度和持续活动水平，将Warm细胞与其他类型的脊髓丘脑I层神经元区分开来。温暖细胞的放电与已知的人类温暖感知的心理物理学相比较，这些神经元可能对区别性热接受至关重要。此外，在体温调节的作用，哺乳动物体内平衡的定义特征，提出。
1. In order to further characterize the role of lamina I as the source of central ascending neural pathways for thermoreception and thermoregulation, experiments were performed on anaesthetized cats to determine the quantitative response characteristics of warming-specific lumbosacral spinothalamic lamina I neurones.2. We identified 10 neurones out of 474 that were selectively excited by cutaneous warming (Warm cells). Their thresholds were all in the range 35-37 degreesC at a baseline of 34.5 degreesC, and their discharge linearly encoded the temperature of graded, innocuous warming stimuli with a sensitivity of 2.1 Hz degreesC(-1).3. The stimulus-response function of the Warm cells plateaued at temperatures that were in the noxious heat range.4. The Warm cells were distinguished from other classes of spinothalamic lamina I neurones by their peripheral inputs, central conduction velocities and level of ongoing activity.5. The discharge of Warm cells compares well with the known human psychophysics of warm sensibility, and these neurones are likely to be crucial to discriminative thermoreception. Additionally, a role in thermoregulation, a defining feature of mammalian homeostasis, is suggested.