Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells.
Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells.
复制标题
Ouabain刺激的肾近端小管细胞中Na/K-ATPase和NHE3的运输调节。
DOI：
10.1007/s11010-012-1331-x
复制
发表时间：
2012-08
影响因子：
4.3
通讯作者：
Liu, Jiang
中科院分区：
文献类型：
--
作者：
Yan, Yanling;Haller, Steven;Shapiro, Anna;Malhotra, Nathan;Tian, Jiang;Xie, Zijian;Malhotra, Deepak;Shapiro, Joseph I.;Liu, Jiang
We have demonstrated that ouabain regulates protein trafficking of the Na/K-ATPase α1 subunit and NHE3 (Na/H exchanger, isoform 3) via ouabain-activated Na/K-ATPase signaling in porcine LLC-PK1 cells. To investigate whether this mechanism is species-specific, ouabain-induced regulation of the α1 subunit and NHE3 as well as transcellular 22Na+ transport were compared in three renal proximal tubular cell lines (human HK-2, porcine LLC-PK1, and AAC-19 originated from LLC-PK1 in which the pig α1 was replaced by ouabain-resistant rat α1). Ouabain inhibited transcellular 22Na+ transport due to an ouabain-induced redistribution of the α1 subunit and NHE3. In LLC-PK1 cells, ouabain also inhibited the endocytic recycling of internalized NHE3, but has no significant effect on recycling of endocytosed α1 subunit. These data indicated that the ouabain-induced redistribution of the α1 subunit and NHE3 is not a species-specific phenomenon, and ouabain-activated Na/K-ATPase signaling influences NHE3 regulation.
登录
查看更多内容
影响因子：
21.1
作者：
Bagrov AY;Shapiro JI;Fedorova OV
通讯作者：
Fedorova OV
影响因子：
5.6
作者：
Aperia, A
通讯作者：
Aperia, A
影响因子：
15.9
作者：
HARRIS, RC;BRENNER, BM;SEIFTER, JL
通讯作者：
SEIFTER, JL
DOI：
10.1016/j.bbadis.2010.01.013
发表时间：
2010-12
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Liu J;Xie ZJ
通讯作者：
Xie ZJ
影响因子：
4.8
作者：
Liang, Man;Cai, Ting;Xie, Zi-Jian
通讯作者：
Xie, Zi-Jian