A randomized controlled trial of combined executive function and memory training on the cognitive and noncognitive function of individuals with mild cognitive impairment: Study rationale and protocol design.
A randomized controlled trial of combined executive function and memory training on the cognitive and noncognitive function of individuals with mild cognitive impairment: Study rationale and protocol design.
复制标题
DOI：
10.1016/j.trci.2018.09.004
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Zhang H;Wang J;Sun T;Wang Z;Lyu X;Yu X;Wang H
认知训练作为一种安全、经济、可扩展的非药物干预措施，在轻度认知障碍（MCI）患者中引起了相当大的关注。然而，还没有研究足够重视执行功能的训练。本研究旨在评估记忆训练与执行训练相结合是否可以改善MCI患者的认知和非认知表现。此外，我们将探讨神经相关的变化表现。这项研究是一项随机对照试验，将包括120名MCI患者。符合条件的患者将被随机分配到干预组或候补对照组。干预组将接受计算机化的综合训练（执行功能和记忆），共96次，为期24周以上。对照组在研究期间不接受任何干预。将在基线和干预24周后进行行为数据收集和磁共振成像/脑电图/近红外光谱扫描。这项研究目前正在进行中。招募于2017年7月开始，将于2018年12月结束。如果联合训练能使MCI患者的认知功能和非认知功能发生积极变化，这可能代表了一种延缓认知功能下降的新方法，甚至可能为痴呆症的预防提供一种潜在的方法。此外，对任何与训练相关的结构变化或功能变化的评估将有助于揭示组合认知训练的潜在机制。本研究注册于Clinicaltrials.gov（标识符：NCT 03232047，2017年8月18日）。
Cognitive training has attracted considerable attention as a safe, economical, and scalable nonpharmacologic intervention in patients with mild cognitive impairment (MCI). However, no study has yet placed sufficient emphasis on the training of executive function. The present study aimed to evaluate whether memory training combined with executive training could lead to improved cognitive and noncognitive performance in patients with MCI. Furthermore, we will explore the neural correlates underlying the changed performances. The proposed study is a randomized controlled trial that will include 120 patients with MCI. The eligible patients will be randomized to either an intervention group or a waitlist control group. The intervention group will receive computerized combined training (executive function and memory) for 96 sessions for more than 24 weeks. The control group will receive no intervention during the research period. Behavior data collection and a magnetic resonance imaging/electroencephalogram/near-infrared spectroscopy scan will be performed at baseline and after 24 weeks of intervention. The study is currently ongoing. Recruitment began in July 2017 and will conclude in December 2018. If combined training results in positive changes to cognitive function and noncognitive function in patients with MCI, this might represent a new approach to delay the cognitive decline or even provide a potential method for dementia prevention. Furthermore, the evaluation of any training-related structural changes or functional changes will help to reveal the mechanisms underlying the combined cognitive training. This study was registered with Clinicaltrials.gov (Identifier: NCT03232047, August 18, 2017).