H-2-linked resistance to mastocytoma in male mice: immune response to a histocompatibility antigen on the X chromosome.
H-2-linked resistance to mastocytoma in male mice: immune response to a histocompatibility antigen on the X chromosome.
复制标题
雄性小鼠 H-2 相关的肥大细胞瘤抗性：对 X 染色体上组织相容性抗原的免疫反应。
DOI：
10.1126/science.6405481
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Williams,RM
中科院分区：
文献类型：
--
作者：
Kwak,LW;Kucuk,O;Melvold,RW;Williams,RM
菌株C57BL/6Kh雌性小鼠与菌株DBA/2J雄性小鼠杂交后，雄性小鼠在注射DBA/2来源的P815肥大细胞瘤细胞后的寿命比雌性小鼠长。DBA/2菌株对X染色体组织相容性抗原的应答可能参与了对肿瘤的抵抗。当雌性亲本被携带h -2区域突变之一的C57BL/6Kh取代时，这种性别效应在一些杂交组合中消失了。因此，在这种肿瘤模型中，h -2复合物似乎参与了对x连锁组织相容性抗原的免疫反应的调节。
Male hybrids from a cross between female mice of strain C57BL/6Kh and males of strain DBA/2J lived longer after injection of P815 mastocytoma cells of DBA/2 origin than did their female siblings. Responses to the histocompatibility antigen on the X chromosome of the DBA/2 strain may be involved in resistance to the tumor. When the female parent was replaced with a C57BL/6Kh carrying one of several mutations in theH-2region, this sex effect disappeared in some of the hybrid combinations. Thus, theH-2complex appears to be involved in the regulation of the immune response to the X-linked histocompatibility antigen in this tumor model.