Regression of melanoma nodules in a patient treated with ranitidine.
Regression of melanoma nodules in a patient treated with ranitidine.
复制标题
接受雷尼替丁治疗的患者黑色素瘤结节消退。
作者：
T. Smith;J. Clark;M. Popp
人类恶性黑色素瘤可以自发消退，也可以通过免疫疗法消退，例如卡介苗、干扰素α、白细胞介素2、白细胞介素2加淋巴因子激活的杀伤细胞。组胺 2 型受体拮抗剂可以通过抑制抑制性 T 细胞的诱导和活性来调节免疫功能，据报道，在使用西咪替丁与香豆素或干扰素 α 后，黑色素瘤会消退。本文描述了一位接受另一种组胺 2 型受体拮抗剂盐酸雷尼替丁治疗的患者黑色素瘤结节的完全消退。在临床试验的设计和评估中，应将雷尼替丁和西咪替丁视为可能的活性免疫治疗药物。
Human malignant melanoma may regress spontaneously or with immunotherapy, such as Calmette-Guerin bacillus, interferon alfa, interleukin-2, and interleukin-2 plus lymphokine-activated killer cells. Histamine type 2 receptor antagonists can modulate immune function by inhibiting suppressor T-cell induction and activity, and melanoma regressions have been reported after the use of cimetidine with coumarin or interferon alfa. This article describes the complete regression of melanoma nodules in a patient treated with ranitidine hydrochloride, another histamine type 2-receptor antagonist. Ranitidine and cimetidine should be considered to be possibly active immunotherapeutic agents in the design and evaluation of clinical trials.