Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
Antimicrobial-Resistant Pathogens Associated with Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
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DOI：
10.1086/668770
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发表时间：
2013-01-01
影响因子：
4.5
通讯作者：
Fridkin, Scott
中科院分区：
文献类型：
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作者：
Sievert, Dawn M.;Ricks, Philip;Fridkin, Scott
OBJECTIVE.描述2009- 2010年美国国家医疗安全网络（NHSN）报告的医疗相关感染（HAI）的耐药模式。包括中心静脉导管相关血流感染、导管相关尿路感染、呼吸机相关肺炎和手术部位感染。按HAI类型计算对选定抗菌药物耐药（或在某些情况下不敏感）的分离株的合并平均比例，并与历史数据进行比较。总体而言，2，039家医院报告了1起或多起HAI; 1，749家（86%）为普通急症护理医院，1，143家（56%）床位少于200张。报告了69，475例HAI和81，139例病原体。8个病原菌群约占报告病原菌的80%：金黄色葡萄球菌（16%），肠球菌属（16%）。(14%）、大肠埃希菌（12%）、凝固酶阴性葡萄球菌（11%）、念珠菌属（11%）。（9%）、肺炎克雷伯菌（和产酸克雷伯菌; 8%）、铜绿假单胞菌（8%）和肠杆菌属（Enterobacter spp.）（百分之五）。耐药率与前2年报告的相似，但耐药率略有下降。耐苯唑西林金黄色葡萄球菌（MRSA）。近20%的HAI报告的病原体为以下多重耐药表型：MRSA（8.5%）;万古霉素耐药肠球菌（3%）; pneumoniae和K.催产素E.大肠杆菌（2%）和肠杆菌属（2%）。耐碳青霉烯类的铜绿假单胞菌（2%）、克雷伯菌（2%）。pneumoniae/oxytoca（
OBJECTIVE. To describe antimicrobial resistance patterns for healthcare-associated infections (HAIs) reported to the National Healthcare Safety Network (NHSN) during 2009-2010.METHODS. Central line-associated bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and surgical site infections were included. Pooled mean proportions of isolates interpreted as resistant (or, in some cases, nonsusceptible) to selected antimicrobial agents were calculated by type of HAI and compared to historical data.RESULTS. Overall, 2,039 hospitals reported 1 or more HAIs; 1,749 (86%) were general acute care hospitals, and 1,143 (56%) had fewer than 200 beds. There were 69,475 HAIs and 81,139 pathogens reported. Eight pathogen groups accounted for about 80% of reported pathogens: Staphylococcus aureus (16%), Enterococcus spp. (14%), Escherichia coli (12%), coagulase-negative staphylococci (11%), Candida spp. (9%), Klebsiella pneumoniae (and Klebsiella oxytoca; 8%), Pseudomonas aeruginosa (8%), and Enterobacter spp. (5%). The percentage of resistance was similar to that reported in the previous 2-year period, with a slight decrease in the percentage of S. aureus resistant to oxacillins (MRSA). Nearly 20% of pathogens reported from all HAIs were the following multidrug-resistant phenotypes: MRSA (8.5%); vancomycin-resistant Enterococcus (3%); extended-spectrum cephalosporin-resistant K. pneumoniae and K. oxytoca (2%), E. coli (2%), and Enterobacter spp. (2%); and carbapenem-resistant P. aeruginosa (2%), K. pneumoniae/oxytoca (