Radiation Modifiers
Radiation Modifiers
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DOI：
10.1016/j.hoc.2019.08.004
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发表时间：
2019-12-01
影响因子：
2.4
通讯作者：
Citrin, Deborah E.
中科院分区：
文献类型：
--
作者：
Citrin, Deborah E.
放射治疗是癌症最常用的治疗方法之一。辐射调节剂是改变肿瘤或正常组织对辐射的反应的试剂，如辐射敏感剂和辐射保护剂。辐射增敏剂靶向肿瘤分子生物学或生理学方面，以增强辐射后肿瘤细胞的杀伤力。辐射防护器选择性地防止对正常组织的损害。目前，辐射调节剂在很大程度上仍处于研究阶段，有望通过对肿瘤的分子表征来增强成功临床开发的能力。描述了各种辐射改进剂。
Radiation therapy is one of the most commonly used treatments for cancer. Radiation modifiers are agents that alter tumor or normal tissue response to radiation, such as radiation sensitizers and radiation protectors. Radiation sensitizers target aspects of tumor molecular biology or physiology to enhance tumor cell killing after irradiation. Radioprotectors prevent damage of normal tissues selectively. Radiation modifiers remain largely investigational at present, with the promise that molecular characterization of tumors may enhance the capacity for successful clinical development moving forward. A variety of radiation modifiers are described.