Small-molecule pheromones that control dauer development in Caenorhabditis elegans
Small-molecule pheromones that control dauer development in Caenorhabditis elegans
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DOI：
10.1038/nchembio.2007.3
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发表时间：
2007-07-01
影响因子：
14.8
通讯作者：
Clardy, Jon
中科院分区：
文献类型：
--
作者：
Butcher, Rebecca A.;Fujita, Masaki;Clardy, Jon
为了应对高人口密度或低食物供应，线虫秀丽隐杆线虫进入另一个幼虫阶段，称为dauer，可以长时间承受不利条件。C.秀丽线虫通过一种小分子信号来感知其种群密度，这种信号传统上被称为道尔信息素，它分泌到周围环境中。在这里，我们表明，dauer信息素由几个结构相关的ascarosides -双脱氧糖ascarylose的衍生物-和这些ascarosides（1和2）是大约两个数量级更有效地诱导dauer形成比以前报道的dauer信息素成分（3），并构成生理相关的信号。鉴别dauer信息素组分1和2将有助于鉴定靶受体和下游信号蛋白。
In response to high population density or low food supply, the nematode Caenorhabditis elegans enters an alternative larval stage, known as the dauer, that can withstand adverse conditions for prolonged periods. C. elegans senses its population density through a small-molecule signal, traditionally called the dauer pheromone, that it secretes into its surroundings. Here we show that the dauer pheromone consists of several structurally related ascarosides - derivatives of the dideoxysugar ascarylose - and that two of these ascarosides ( 1 and 2) are roughly two orders of magnitude more potent at inducing dauer formation than a previously reported dauer pheromone component ( 3) and constitute a physiologically relevant signal. The identification of dauer pheromone components 1 and 2 will facilitate the identification of target receptors and downstream signaling proteins.