Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes.
Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes.
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DOI：
10.4061/2011/625210
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发表时间：
2011
影响因子：
--
通讯作者：
Duina AA
中科院分区：
文献类型：
--
作者：
Duina AA
基因转录过程需要大量因子的参与，这些因子共同促进生物体遗传信息的准确和有效表达。在真核细胞中，这些因子的子集可以控制基因的调控和转录单位的染色质环境，以调节转录过程并确保正确利用潜在的遗传信息。本文重点介绍两个这样的因素-高度保守的组蛋白伴侣Spt 6和FACT-that发挥关键作用，在基因转录过程中管理染色质。这些因子在转录过程中具有相关但不同的功能，最近的几项研究为它们在转录基因中的作用机制提供了令人兴奋的新见解。讨论了它们各自在调节基因转录中的作用，包括它们对这一过程的共同和独特的贡献。
The process of gene transcription requires the participation of a large number of factors that collectively promote the accurate and efficient expression of an organism's genetic information. In eukaryotic cells, a subset of these factors can control the chromatin environments across the regulatory and transcribed units of genes to modulate the transcription process and to ensure that the underlying genetic information is utilized properly. This article focuses on two such factors—the highly conserved histone chaperones Spt6 and FACT—that play critical roles in managing chromatin during the gene transcription process. These factors have related but distinct functions during transcription and several recent studies have provided exciting new insights into their mechanisms of action at transcribed genes. A discussion of their respective roles in regulating gene transcription, including their shared and unique contributions to this process, is presented.