GLOMERULAR MATRIX - SYNTHESIS, TURNOVER AND ROLE IN MESANGIAL EXPANSION
GLOMERULAR MATRIX - SYNTHESIS, TURNOVER AND ROLE IN MESANGIAL EXPANSION
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DOI：
10.1038/ki.1994.42
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发表时间：
1994-02-01
影响因子：
19.6
通讯作者：
MCCARTHY, KJ
中科院分区：
文献类型：
--
作者：
COUCHMAN, JR;BEAVAN, LA;MCCARTHY, KJ
细胞外基质在肾小球的发育、稳态和病理中具有不可或缺的作用。肾小球中存在三种空间上不同的基质：系膜、毛细血管袢和鲍曼氏囊的基底膜。每一种都由基底膜成分主导，但在组织和组成上不同。许多基质成分通过与受体的特异性相互作用直接影响细胞行为，或通过生长因子螯合间接影响细胞行为。生长因子在肾小球的发育和疾病进展中可能非常重要，并且可能是系膜扩张的中心。此外，基质组成的变化伴随并促成病理状况，例如糖尿病中基质的积累。
The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.