Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia
Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia
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DOI：
10.1111/j.1471-0528.1998.tb09974.x
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发表时间：
1998-11-01
期刊：
影响因子：
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通讯作者：
Redman, CWG
中科院分区：
文献类型：
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作者：
Morris, JM;Gopaul, NK;Redman, CWG
目的探讨当采取适当的预防措施以防止体外氧化时，氧化应激的循环标志物是否升高。设计一项前瞻性研究，设牛津大学纳菲尔德妇产科和伦敦威廉·哈维研究所。随机分为三组：先兆子痫组(n=19)，与妊娠、年龄和产次匹配的对照组(n=19)，以及一组非妊娠的育龄个体(n=7)。测定血浆8-前列腺素F-2α、过氧化脂质、丙二醛及脂溶性抗氧化剂维生素E水平。结果子痫前期组与正常妊娠组血浆8-前列腺素F-2α、过氧化脂质、丙二醛水平无明显差异。然而，与非妊娠妇女相比，子痫前期组和正常妊娠组的脂质过氧化产物和丙二醛水平均显著升高。子痫前期组和正常妊娠组维生素E水平相似，但均显著高于非妊娠组。结论正常妊娠和子痫前期患者氧化应激循环标志物水平升高。
Objective To determine whether circulating markers of oxidative stress are elevated in preeclampsia when appropriate precautions are taken to prevent in vitro oxidationDesign A prospective study.Setting Nuffield Department of Obstetrics and Gynaecology, Oxford and The William Harvey Institute, London.Sample Three groups of women: those with pre-eclampsia (n = 19), control pregnant women (n = 19) matched for gestation, age and parity and a group of non pregnant individuals of reproductive age (n = 7).Methods Citrated plasma was stored at -80 degrees C with 20 mu mol beta hydroxytoluene to prevent autooxidation. Plasma samples were assayed for levels of 8 epi-prostaglandin F-2 alpha, lipid hydroperoxides, malondialdehyde and also the lipid soluble antioxidant vitamin E.Results There were no differences in 8 epi-prostaglandin F-2 alpha, lipid peroxide or malondialdehyde levels between the groups of women with pre-eclampsia and those acting as pregnant controls. However, lipid hydroperoxides and malondialdehyde were significantly raised in both preeclampsia and normal pregnancy, compared with nonpregnant women. Vitamin E levels were similar in women with pre-eclampsia and those with a normal pregnancy, but in both groups levels were significantly higher than in nonpregnant women.Conclusion Circulating markers of oxidative stress are raised in normal pregnancy and preeclampsia.