Rapid determination of residual monomer in polylactide using thermogravimetric analysis
Rapid determination of residual monomer in polylactide using thermogravimetric analysis
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DOI：
10.1016/j.polymertesting.2012.03.010
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发表时间：
2012-08
期刊：
影响因子：
5.1
通讯作者：
Feng Lidong;Gao Li;Xinchao Bian;Zhiming Chen;L. Yanlong;Yi Cui;Xuesi Chen
中科院分区：
文献类型：
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作者：
Feng Lidong;Gao Li;Xinchao Bian;Zhiming Chen;L. Yanlong;Yi Cui;Xuesi Chen
建立了一种用热重分析（TGA）定量测定聚乳酸（PLA）中残留单体的方法。PLA中的丙交酯单体在低于PLA的分解温度下完全蒸发，因此可以通过PLA的热谱图来确定单体含量。大量的实验表明，残留单体含量等于在10 °C/min的扫描速率下从100 °C到250 °C的重量损失百分比。通过进行平行实验评估了测量可靠性，TGA结果与HPLC获得的测试数据吻合良好。在高含量（4.68%~ 10.33%）时，相对标准偏差（RSD）<8.0%;在低含量（0.3%）时，RSD <18%。
A method has been developed to quantitatively determine the residual monomer in polylactide (PLA) using thermogravimetric analysis (TGA). The lactide monomer in PLA is evaporated completely below the decomposition temperature of PLA, thus the monomer content can be determined with a thermogram of PLA. Extensive experiments show that the residual monomer content is equal to the percent weight loss from 100 °C to 250 °C at a scanning rate of 10 °C/min. The measurement reliability has been evaluated by conducting parallel experiments and the results from TGA are in good agreement with the test data obtained using HPLC. The relative standard deviation (RSD) of the measurements is <8.0% at high contents (4.68%–10.33%), while RSD is <18% at a low level (0.3%), which indicates that the method is sufficiently precise for rapid determination of the residual monomer in PLA.