Wash-in rate on the basis of dynamic contrast-enhanced MRI: Usefulness for prostate cancer detection and localization
Wash-in rate on the basis of dynamic contrast-enhanced MRI: Usefulness for prostate cancer detection and localization
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DOI：
10.1002/jmri.20431
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发表时间：
2005-11-01
影响因子：
4.4
通讯作者：
Cho, KS
中科院分区：
文献类型：
--
作者：
Kim, JK;Hong, SS;Cho, KS
用途：目的：探讨动态增强MRI（dynamic contrast enhanced MRI，DCE）的洗入率（wash-in rate）对前列腺癌（prostate cancer.Materials and Methods）的诊断价值。过渡区的内部和过渡区的外部）。根据这些数据。生成参数成像，然后将其用于癌症检测和定位的准确性与不使用直肠内线圈的T-2加权成像的准确性进行比较。结果：前列腺癌组织的洗入率（9.2/s）明显高于正常前列腺组织（3.3/s、6.7/s）。和3.2次/秒; P < 0.001）。在整个前列腺（分别为96%和82% vs. 65%和60%）和外周区（分别为96%和97% vs. 75%和53%：P < 0.05），参数成像的洗入率的敏感性和特异性高于T2加权成像。在移行区，参数成像的敏感性（96%）高于T2加权成像（45%：P = 0.016），但特异性相似（51%比73%：P = 0.102）。结论：基于DCE-MRI的洗入率是一个有用的参数前列腺癌的检测和定位。
Purpose: To evaluate the usefulness of the wash-in rate based on dynamic contrast-enhanced (DCE) MRI for the detection and localization of prostate cancer.Materials and Methods: In 53 patients, the wash-in rate was measured in the cancer area and in three normal areas (the peripheral zone. inner portion of the transitional zone, and outer portion of the transitional zone). On the basis of these data. parametric imaging was generated and then its accuracy for cancer detection and location was evaluated compared to that of T-2-weighted imaging without the use of an endorectal coil. For that purpose the entire prostate was divided into 18 segments.Results: The wash-in rate value was greater in cancer tissue (9.2/second) than in three normal tissues (3.3/second, 6.7/second. and 3.2/second, respectively; P < 0.001). The sensitivity and specificity were greater on parametric imaging of the wash-in rate compared to T2-weighted imaging in the entire prostate (96% and 82% vs. 65% and 60%, respectively) and the peripheral zone (96% and 97% vs. 75% and 53%: P < 0.05). In the transitional zone, the sensitivity was greater on parametric imaging (96%) than on T2-weighted imaging (45%: P = 0.016), but the specificity was similar (51% vs. 73%: P = 0.102).Conclusion: The wash-in rate based on DCE-MRI is a useful parameter for prostate cancer detection and localization.