Reduction of striatal dopamine release during an ethanol withdrawal syndrome
Reduction of striatal dopamine release during an ethanol withdrawal syndrome
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乙醇戒断综合征期间纹状体多巴胺释放减少
作者：
J. Darden;W. A. Hunt
在急性和慢性乙醇治疗后，观察到脑中儿茶酚胺功能的改变。虽然对DA和NE水平没有显著影响（BONNYCASTLE等人，1962; EFRON & GESSA，1963; DURITZ & TRUIIT，1966），乙醇似乎以双相方式诱导儿茶酚胺周转的变化。单剂量在治疗后不久增加NE周转，观察到对DA周转的升高或无影响（CORRODI等人，1966; CARLSSON等人，1973; Hunt & Majchrowicz，1974; POHORECKY & JAFFE，1975）。几小时后，NE和DA的周转率均降低
ALTERATIONS in catecholamine function in the brain have been observed after acute and chronic treatment of ethanol. Although there is no significant effect on DA and NE levels (BONNYCASTLE et at., 1962; EFRON & GESSA, 1963; DURITZ & TRUIIT, 1966), ethanol appears to induce changes in catecholamine turnover in a biphasic manner. Single doses increase NE turnover shortly after treatment with an elevation or no effect observed on DA turnover (CORRODI et al., 1966; CARLSSON et al., 1973; HUNT & MAJCHROWICZ, 1974; POHORECKY & JAFFE, 1975). Several hours later both NE and DA turnover are depressed