The behaviour and cholinesterase inhibitory activity of fenthion and its products by light and chlorination
The behaviour and cholinesterase inhibitory activity of fenthion and its products by light and chlorination
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倍硫磷及其产品的光和氯化行为及其抑制胆碱酯酶活性
DOI：
10.2166/aqua.2008.031
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Nishimura
中科院分区：
文献类型：
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作者：
Maiko Tahara;R. Kubota;H. Tokunaga;H. Nakazawa;T. Nishimura
建立了固相萃取-液相色谱/质谱联用技术定量分析水样中倍硫磷及其相关化合物的方法。使用该方法，定量限的值范围为0.2至100 ng l-1。使用这种方法，我们研究了MPP在水中的命运和光照射和氯化产生的产品。MPP在水中逐渐下降，48小时后达到初始浓度的50%。特别地，形成MPP-亚砜。MPP在光照下迅速分解为MPP-亚砜、O，O -二甲基S -[3-甲基-4-（甲硫基）苯基]硫代磷酸酯等化合物。氯化后MPP分解为MPP-亚砜、MPP-砜和它们的氧合物。oxons的浓度以时间依赖性的方式增加。MPP、MPP-亚砜和MPP-砜对胆碱酯酶的抑制作用较弱，而它们的氧杂环对胆碱酯酶的抑制作用较强。人们担心MPP及其产物存在于环境水中，是消毒处理过程中产生的。综合评价MPP及其相关化合物的毒性对了解MPP对生态系统和人类健康的影响具有重要意义。
We established a method for quantitative analysis of fenthion (MPP) and its related compounds in water samples, using solid-phase extraction and liquid chromatography/mass spectrometry. With this method, the values of the limit of quantification ranged from 0.2 to 100 ng l−1. Using this method, we examined the fate of MPP in water and the products produced by light irradiation and chlorination. MPP decreased gradually and reached 50% of the initial concentration after 48 hours in water. In particular, MPP-sulfoxide was formed. With light irradiation, MPP decomposed immediately into MPP-sulfoxide, O,O -Dimethyl S -[3-methyl-4-(methylthio)phenyl]phosphorothioate and other compounds. With chlorination, MPP decomposed into MPP-sulfoxide, MPP-sulfone, and their oxons. The concentration of oxons increased in a time-dependent manner. In their effects on organisms, MPP, MPP-sulfoxide and MPP-sulfone showed weak inhibitory activity to cholinesterase, whereas their oxons showed strong activity. It is feared that MPP and its products exist in environmental water and are produced by the disinfection treatment process. Comprehensive evaluation of the toxicity of MPP and its related compounds is important in order to understand the effects of MPP on ecosystems and human health.