Some observations on anemia in rheumatoid arthritis.
Some observations on anemia in rheumatoid arthritis.
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关于类风湿性关节炎贫血的一些观察。
DOI：
10.1182/blood.v8.6.502.502
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发表时间：
1953
期刊：
影响因子：
20.3
通讯作者：
M. Jeffrey
中科院分区：
文献类型：
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作者：
M. Jeffrey
1.对类风湿关节炎贫血的某些方面的调查结果进行了报道和讨论。
2.贫血以红细胞正常、色素减退为主，平均红细胞体积正常，平均血红蛋白含量和浓度降低。贫血在疾病非常活跃的情况下更为明显。
3.不适当的溶血不重要。
4.骨髓象未见明显异常，但提示正常母细胞成熟受阻，血红蛋白形成受阻。
5.血容量和血浆容量没有本质上的异常，尽管频繁的虚弱习惯性和体重减轻可能会产生明显的体重升高。在贫血较重的病例中，发现许多贫血的共同改变，即正常的血浆容量，但红细胞和全血容量减少。
6.血浆铁浓度通常降低，在疾病非常活跃或有明显贫血的病例中，低于正常值的情况不变。
7.血清铁结合能力可因缺铁而升高或略有降低，但不足以成为产生或维持贫血的因素。
8.根据血浆铁的变化判断，单次最大治疗剂量后，肠道对铁的吸收是不同的。部分病例表现出单纯性铁缺乏症良好的吸收和治疗反应特点。其他人给出了吸收受损的强有力的推定证据。
1. The results of investigations upon some aspects of anemia in rheumatoid arthritis are reported and discussed.
2. The anemia was essentially normocytic and hypochromic, the mean corpuscular volume being usually normal and the mean corpuscular hemoglobin content and concentration usually reduced. Anemia was more pronounced in the presence of very active disease.
3. Undue hemolysis was not of importance.
4. The myelogram showed no gross abnormality but suggested impaired maturation of normoblasts and retarded hemoglobin formation.
5. The blood and plasma volumes were not essentially abnormal, though the frequent asthenic habitus and loss of weight might produce apparently exalted values in terms of body weight. In the more anemic cases, changes common to many anemias were found, viz., normal plasma volume with decreased corpuscle and whole blood volume.
6. The plasma iron concentration was usually reduced; subnormal values were invariable in cases with very active disease or marked anemia.
7. The iron-binding capacity of the serum might be raised by iron deficiency or slightly reduced but not enough to be a factor in producing or maintaining anemia.
8. As judged by changes in the plasma iron, intestinal absorption of iron after a single maximal therapeutic dose was variable. Some cases showed the excellent absorption and therapeutic response characteristic of simple iron deficiency. Others gave strong presumptive evidence of impaired absorption.